Cancer Clinical Trial
Official title:
A Phase 1 Study of APX3330 in Patients With Advanced Solid Tumors
This is a Phase 1, multi-center, open-label, dose-escalation oncology study of APX3330 in patients with advanced solid tumors.
Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is a protein that regulates
multiple transcription factors involved in cancer cell signaling and APX3330 is a highly
selective inhibitor of APE1/Ref-1 redox function.
The anti-tumor effect of APX330 has been demonstrated in a variety of preclinical models and
the human safety profile of APX3330 was established in prior clinical studies. Apexian
Pharmaceuticals is developing APX3330 as an orally administered anti-cancer agent targeting
the APE1/Ref-1 protein.
APX_CLN_0011 is a Phase 1, multi-center, open-label, dose-escalation oncology study in
patients with advanced solid tumors. The study primary objective is to determine the
recommended Phase 2 study dose of APX3330. Secondary objectives include assessment of APX3330
safety, anti-tumor activity, pharmacokinetic and pharmacodynamic profile.
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