Cancer Clinical Trial
Official title:
Time of Treatment With Low Molecular Weight Heparins in Cancer Patients With Thromboembolic Disease. Procoagulant Role of Phospholipid-dependent Microparticles.
Cancer is the most important acquired risk factor of thromboembolisms. More than 20% of all
episodes of venous thromboembolism (VT) or pulmonary thromboembolisms (PT) are cancer
related. Cancer patients with VT or PT are treated with low molecular weight heparins (LMWH)
during at least 3 months, but nowadays the duration of treatment is not accurately
determined.
The D-Dimer determination has been used like recurrence predictors after LMWH treatment
suspension, but in cancer patients the useful is limited. Phospholipid-dependent
microparticles could been used like recurrence predictors in cancer patients and tailored
the duration of LMWH treatment for each patient.
We are carrying out a study in Cancer-associated-thromboembolism patients in order to decide the suitable anticoagulation time. A set of exclusion criteria is being used to determine in which patients LMWH will be withdrawn. Patients are being followed after LMWH withdrawal until 6 months. Blood samples are being taken at baseline (LMWH withdrawal), 3 weeks and 3 months after. We will look for association between several biomarkers and venous thromboembolism recurrences. ;
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