Cancer Clinical Trial
Official title:
Effects of Reappraisal, Reassurance, and Distraction on Pain and Distress in Children Undergoing Treatment for Cancer
This study tested the effects of emotion regulation strategies (reappraisal, reassurance, and empathy) on pain responses in children with cancer. Children with cancer were randomly assigned to one emotion regulation strategy during an experimental pain task (the cold pressor task [CPT]). During the CPT, children rated their pain and provided saliva samples immediately before, after, and then 15 minutes after the CPT. This study examined the influence of emotion regulation on self-reported pain and physiological activity assessed through saliva samples.
More than 12,000 children are diagnosed with cancer in the United States each year and the
majority of these children will experience pain throughout their illness. Children with
cancer are required to undergo repeated invasive medical procedures, including bone marrow
aspirations (BMA) and lumbar punctures (LP), which have been described by children as the
most distressing and painful aspect of their illness. The experience and memory of
procedural pain can have a lasting effect and impact distress in future procedures; children
learn to anticipate pain and show increased distress and decreased cooperation at subsequent
procedures. Moreover, childhood medical distress has also been linked to adults' reports of
pain and fear around medical events and even avoidance of future health care. Early painful
procedures have also been associated with behavioral changes to medical events later in
life, a finding that is supported by recent physiological evidence indicating that
activation of the pain processing system in the brain can change neuropathways, which leads
to increased sensitivity to later stimulation of pain systems. Therefore, it is vital to
develop strategies to minimize the pain and distress that children undergo through cancer
treatment and understanding the impact of children's memory on pain is a crucial step in
this process.
To address this important need, this study involved identifying the strategies that children
use to cope with distress that promote positive memories of medical events, examining how
these strategies impact their immediate physiology (via salivary biomarkers) and
self-reported pain, and understanding how these coping strategies change children's distress
over time during future medical procedures. Specifically, certain coping strategies change
the way that children interpret stressful medical procedures, which affects the emotional
response to future procedures. These objectives were accomplished by the following specific
aims:
Aim 1: Identify emotion-regulation (i.e., coping) strategies that promote more positive
memories of distressing medical procedures in children with cancer.
Aim 2: Assess the impact of emotion-regulation strategies on children's distress response to
painful procedures over time.
This project will provide specific means for impacting children's pain and distress during
medical procedures. Specifically, because the emotion regulation strategies described in
this protocol are modifiable and teachable, they provide direct implications for clinical
practice in pain management by identifying strategies that can decrease children's pain and
anxiety throughout their course of cancer treatment.
;
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT05346796 -
Survivorship Plan HEalth REcord (SPHERE) Implementation Trial
|
N/A | |
Recruiting |
NCT05094804 -
A Study of OR2805, a Monoclonal Antibody Targeting CD163, Alone and in Combination With Anticancer Agents
|
Phase 1/Phase 2 | |
Completed |
NCT04867850 -
Effect of Behavioral Nudges on Serious Illness Conversation Documentation
|
N/A | |
Enrolling by invitation |
NCT04086251 -
Remote Electronic Patient Monitoring in Oncology Patients
|
N/A | |
Completed |
NCT01285037 -
A Study of LY2801653 in Advanced Cancer
|
Phase 1 | |
Completed |
NCT00680992 -
Study of Denosumab in Subjects With Giant Cell Tumor of Bone
|
Phase 2 | |
Completed |
NCT00062842 -
Study of Irinotecan on a Weekly Schedule in Children
|
Phase 1 | |
Active, not recruiting |
NCT04548063 -
Consent Forms in Cancer Research: Examining the Effect of Length on Readability
|
N/A | |
Completed |
NCT04337203 -
Shared Healthcare Actions and Reflections Electronic Systems in Survivorship
|
N/A | |
Recruiting |
NCT04349293 -
Ex-vivo Evaluation of the Reactivity of the Immune Infiltrate of Cancers to Treatments With Monoclonal Antibodies Targeting the Immunomodulatory Pathways
|
N/A | |
Terminated |
NCT02866851 -
Feasibility Study of Monitoring by Web-application on Cytopenia Related to Chemotherapy
|
N/A | |
Active, not recruiting |
NCT05304988 -
Development and Validation of the EFT for Adolescents With Cancer
|
||
Completed |
NCT00340522 -
Childhood Cancer and Plexiform Neurofibroma Tissue Microarray for Molecular Target Screening and Clinical Drug Development
|
||
Recruiting |
NCT04843891 -
Evaluation of PET Probe [64]Cu-Macrin in Cardiovascular Disease, Cancer and Sarcoidosis.
|
Phase 1 | |
Active, not recruiting |
NCT03844048 -
An Extension Study of Venetoclax for Subjects Who Have Completed a Prior Venetoclax Clinical Trial
|
Phase 3 | |
Completed |
NCT03167372 -
Pilot Comparison of N-of-1 Trials of Light Therapy
|
N/A | |
Completed |
NCT03109041 -
Initial Feasibility Study to Treat Resectable Pancreatic Cancer With a Planar LDR Source
|
Phase 1 | |
Terminated |
NCT01441115 -
ECI301 and Radiation for Advanced or Metastatic Cancer
|
Phase 1 | |
Recruiting |
NCT06206785 -
Resting Energy Expenditure in Palliative Cancer Patients
|
||
Recruiting |
NCT05318196 -
Molecular Prediction of Development, Progression or Complications of Kidney, Immune or Transplantation-related Diseases
|