Massive Burns: Retrospective Analysis of Changes in Outcomes Across 18 Years

Burns Clinical Trial

— MassiveBurns  

Official title:

Massive Burns: Retrospective Analysis of Change in Outcomes Across 18 Years

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04480944
• Other study ID #: CER2018-02268
• Status: Completed
• Start date: January 1, 2019
• Est. completion date: March 31, 2020

Study information

• Verified date: July 2020
• Source: Centre Hospitalier Universitaire Vaudois
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Burns treatment and management has evolved since the 90s, particularly for massive burns (≥ 50% of total body surface area (TBSA)). This study aims at analyzing the impact of the management changes on the length of intensive care unit (ICU) stay, the take of skin grafts and the mortality.

Description:

Review of all massively burned patients treated at Lausanne University Hospital burn intensive care unit (ca. 40-60 patients). Analysis of changes in length of intensive care unit stay (LICU), skin graft take rate or mortality between 2000 and 2018.

Hypothesis : the optimization of resuscitation procedures and of nutrition therapy combined with the use of novel surgical techniques has brought a significant improvement in outcomes.

Association between outcomes and year of admission will be assessed through correlation analysis and logistic regression analysis. Potential cofounders will be assessed through stepwise linear regression analysis

Recruitment information / eligibility

• Status: Completed
• Enrollment: 40
• Est. completion date: March 31, 2020
• Est. primary completion date: December 31, 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• All adult patients (>18 years old) with burns =50% TBSA admitted in the burn intensive care unit (ICU) of the Lausanne University Hospital

Exclusion Criteria:

• Patients admitted in the burn center ICU with another primary diagnosis than burn (e.g. necrotizing fasciitis, gangrene, toxic epidermal necrolysis)

• Patients referred from and/or to another ICU

• Patients in which active withdrawal of care was decided within 48h of admission

• Patients with first degree burns only

Related Conditions & MeSH terms

• Burns

Locations

Country	Name	City	State
Switzerland	Adult ICU and Burn ICU, Lausanne University Hospital	Lausanne	Vaud

Sponsors (1)

Lead Sponsor	Collaborator
Mette M Berger

Country where clinical trial is conducted

Switzerland, 

References & Publications (2)

Brusselaers N, Hoste EA, Monstrey S, Colpaert KE, De Waele JJ, Vandewoude KH, Blot SI. Outcome and changes over time in survival following severe burns from 1985 to 2004. Intensive Care Med. 2005 Dec;31(12):1648-53. Epub 2005 Oct 12. — View Citation

Pantet O, Stoecklin P, Vernay A, Berger MM. Impact of decreasing energy intakes in major burn patients: A 15-year retrospective cohort study. Clin Nutr. 2017 Jun;36(3):818-824. doi: 10.1016/j.clnu.2016.05.007. Epub 2016 May 24. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	LICU/Percent TBSA	Ratio between the length of stay in the ICU and the total body surface area burned	18 years
Secondary	Percent TBSA grafted/ Percent TBSA deep burns	Ratio between the TBSA grafted and the deep burns TBSA	18 years
Secondary	Daily nutritional intakes	Daily energy, proteins, lipids and carbohydrates intakes per kilogram of body weight	18 years
Secondary	Mortality	Percentage of patients who received maximal care and died nonetheless	18 years