Burning Nose Clinical Trial
Official title:
The Effectiveness of Topical Lidocaine in Relieving Pain Related To Intranasal Midazolam Sedation: A Randomized, Placebo-Controlled Clinical Trial
Aims: The objective of the current study was to evaluate the effectiveness of topical
lidocaine in relieving pain related to INM administration.
Design: This was a blinded, randomized placebo-controlled trial. Sixty-three uncooperative
children, aged 4 - 11.
Background and Aims: The use of intranasal midazolam (INM) has been commonly associated with
a burning sensation of the nasal mucosa. However, despite its significance, this subject has
received little adequate research focus. The objective of the current study was to evaluate
the effectiveness of topical lidocaine in relieving pain related to INM administration.
Design: This was a blinded, randomized placebo-controlled trial. Sixty-three uncooperative
children, aged 4 - 11, were randomly assigned to one of three groups to receive the drug
nasally via a pre-calibrated spray as per the following assignments:
A: received 0.5 mg/kg midazolam, B: received lidocaine 2% prior to 0.5 mg/kg midazolam.
C: received saline 9% (placebo), 0.5mg/kg. Children were asked to record the degree of pain
using Wong-Baker-Faces- (WBFS) Scale.
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