Human Mesenchymal Stem Cells For Bronchopulmonary Dysplasia

Status Recruiting

Clinical Trial Summary

This study is an open-label, single-center, dose escalation study to evaluate of safety and efficacy of human umbilical cord -derived mesenchymal stem cells (hUC-MSCs) in premature infants for moderate and severe Bronchopulmonary Dysplasia（BPD）.

Clinical Trial Description

BPD is a chronic lung disease that occur in premature infants receiving prolonged oxygen pulmonary and ventilator therapy. It remains a main complication of extreme prematurity and currently lacks efficient treatment.The mortality rate of one year after birth is still high and the quality of life is not optimistic.

hUC-MSCs are widely used in clinic due to their low immunogenicity and convenient to get.Many animal study had shown that hUC-MSCs had therapeutic effects on a variety of animal models of lung disease.Furthermore,there are a large number of clinical trials of MSCs applied to various system diseases and the safety was verified.So,the main purpose of this study is to evaluate the safety and efficacy of hUC-MSCs in participants with moderate and severe BPD. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03558334
Study type	Interventional
Source	Children's Hospital of Chongqing Medical University
Contact	Yunqiu Xia
Phone	13637719980
Email	sunny_199001@foxmail.com
Status	Recruiting
Phase	Phase 1
Start date	June 28, 2018
Completion date	June 30, 2022

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