Breast Cancer Clinical Trial
Official title:
Outcome of Neo-adjuvant Chemotherapy Followed by Breast Conservative Surgery in Breast Cancer in Upper Egypt
Systemic chemotherapy along with radiotherapy has been successfully used to post-operatively
manage patients following tumour resection in breast cancer.
This was further supported with clinical trials conducted in the 1970s and 1980s which shows
significant improvement in progression-free of tumours and overall survival rates in patients
who undergo chemotherapy for operable breast cancer.(1)-(2) Neoadjuvant chemotherapy on the
other hand, involves the administration of the chemotherapeutic agents some weeks before
appropriate breast surgery. This induces reduction in the tumour size and allows for breast
conservative surgery instead of mastectomy in some cases.
Techniques for tumour localization in neoadjuvant chemotherapy using metallic markers
allowing lower excision of breast tissue without compromising margins and breast conservation
being feasible in many patients have evolved over time.(3)-(7)-(9) However, there are recent
concerns questioning the increase use of neoadjuvant chemotherapy in breast cancer it as it
may not be beneficial to patients in the long run.(10)
This will consist of six cycles of FEC-100 regimen followed by surgery. The decision on the
type of surgery (breast conservative surgery or mastectomy) will be taken on the final
assessment of the disease after the six cycle.
Neoadjuvant chemotherapy regimen will consist of six cycles of fluorouracil 500mg/m2 ,
epirubicin 75mg/m2 and cyclophosphamide 500mg/m2 administered intravenously at three week
interval.
Surgery was planned to be performed within 4-6 weeks after the six course of chemotherapy.
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