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Clinical Trial Summary

This multicenter, randomized, comparative study will evaluate the efficacy of denosumab to prevent the adjuvant therapy of aromatase inhibitors-induced loss of bone mineral density (BMD) in breast cancer patients with normal BMD. Investigators will compare the inhibitory effects of denosumab on bone loss between participants with normal BMD to whom Letrozole or Arimidex will be administered as postoperative endocrine therapy for stage I-IIIA postmenopausal hormone-sensitive breast cancer and controls.


Clinical Trial Description

Normal BMD means T score is ≥-1.0 for the lumbar vertebrae (L1-L4) and/or the femoral neck. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03324932
Study type Interventional
Source Kyoto Prefectural University of Medicine
Contact Hisako Ono, PhD
Phone 0752515534
Email hisako-o@koto.kpu-m.ac.jp
Status Recruiting
Phase Phase 3
Start date September 25, 2017
Completion date September 2027

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