Breast Cancer Clinical Trial
Official title:
γδ T Cell Immunotherapy for Treatment of Breast Cancer
In this study, effects of γδT cells on human Breast Cancer in combination with tumor reducing surgery, for example, cryosurgery going to be investigated.
Breast tumor will be removed using tumor reducing surgery such as cryosurgery. PBMC of the
patient will be separated from peripheral blood. After making them potential cancer killer γδ
T Cell, they will be infused to the patients as an immunotherapy treatment NOTE: Originally,
our designed proposal was to use autologous PBMCs from cancer patients to ex vivo expand
Vγ9Vδ2-T cells, and then perform adoptive transfer therapy. However, PBMCs of majority of
cancer patients could not be effectively expanded, including cell number, cell purity and
cell function could not meet the requirements of reinfusion. Meanwhile, those patients could
not tolerate 100ml of blood drawing for culture every 2 ~ 3 weeks.
Therefore, we submitted new clinical study application to the ethical committee of the Fuda
Hospital affiliated with Jinan University (Guangzhou, PR. China) by changing the autologous
protocol with the allogeneic protocol. After the allogeneic protocol was approved, we adapted
allogeneic cells instead of autologous in our subsequentially clinical study.
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