Breast Cancer Clinical Trial
Comparative Effectiveness of Breast Cancer Screening and Diagnostic Evaluation by Extent of Breast Density
|Study type||Observational [Patient Registry]|
|Source||University of California, Davis|
|Contact||Diana L Miglioretti, PhD|
|Start date||September 2016|
|Completion date||September 2021|
This Beast Cancer Surveillance Consortium (BCSC) ADVANCE study is a large, observational pragmatic comparative effectiveness research study using high-quality, prospectively collected data from BCSC registries to generate evidence on how breast density should be integrated into decision making around breast cancer screening and preoperative diagnostic work-up. We will augment existing BCSC registry infrastructure with additional prospective data collection and collection of patient reported outcomes (PROs), CISNET modeling of long-term screening outcomes, and qualitative data from focus groups with women represented in two aims.
Aim 1: Compare the effectiveness of breast cancer screening using digital mammography alone
versus digital mammography plus supplemental screening (digital breast tomosynthesis or MRI)
by extent of breast density.
Sub aim 1: Evaluate whether the performance of tomosynthesis improves with years of experience, and whether any "learning curve" depends on radiologist specialty (i.e., breast imaging specialist vs. general radiologist).
Aim 2: Compare the effectiveness of preoperative MRI versus no MRI by extent of breast density among women with an initial, pathologically confirmed diagnosis of DCIS or invasive breast cancer.
|Completed||NCT00341939 - Retrospective Analysis of a Drug-Metabolizing Genotype in Cancer Patients and Correlation With Pharmacokinetic and Pharmacodynamics Data||N/A|
|Recruiting||NCT01857193 - Phase Ib Trial of LEE011 With Everolimus (RAD001) and Exemestane in the Treatment of Hormone Receptor Positive HER2 Negative Advanced Breast Cancer||Phase 1|
|Terminated||NCT01649258 - Fosaprepitant Dimeglumine and Granisetron Transdermal System in Preventing Nausea and Vomiting in Patients With Breast Cancer Undergoing Chemotherapy||N/A|
|Completed||NCT01943500 - Collection of Blood Specimens for Circulating Tumor Cell Analysis||N/A|
|Active, not recruiting||NCT02371174 - Post-Marketing Surveillance Study of Eribulin on the Status and Factors for the Development of Peripheral Neuropathy in Japan.||N/A|
|Completed||NCT01881230 - Evaluate Risk/Benefit of Nab Paclitaxel in Combination With Gemcitabine and Carboplatin Compared to Gemcitabine and Carboplatin in Triple Negative Metastatic Breast Cancer (or Metastatic Triple Negative Breast Cancer)||Phase 2/Phase 3|
|Recruiting||NCT01967823 - T Cell Receptor Immunotherapy Targeting NY-ESO-1 for Patients With NY-ESO-1 Expressing Cancer||Phase 2|
|Recruiting||NCT02739425 - The Efficacy of Sentimag in Detection of Sentinel Node Biopsy||N/A|
|Not yet recruiting||NCT02767661 - Metronomic Capecitabine Plus Aromatase Inhibitor for First Line Treatment in HR(+), Her2(-) Metastatic Breast Cancer||Phase 3|
|Not yet recruiting||NCT03176888 - Health Benefits of HIT for Breast Cancer Patients||N/A|
|Recruiting||NCT02689427 - Phase IIB Neoadjuvant Enzalutamide (ZT) Plus Taxol for Androgen Receptor (AR)-Positive Triple-Negative Breast Cancer (AR+ TNBC)||Phase 2|
|Recruiting||NCT02903524 - Doxorubicin Hydrochloride Liposome Injection Combination With Cyclophosphamide vs Pirarubicin Combination With Cyclophosphamide in Patients With Locally Advanced Breast Cancer||Phase 4|
|Recruiting||NCT02894398 - Study in Women With Advanced Breast Cancer Receiving Palbociclib With AI or Fulvestrant||Phase 2|
|Recruiting||NCT02897050 - Trial of Neoadjuvant Docetaxel ± Metronomic Capecitabine/CTX Followed by FEC in Women With Operable Triple Negative Breast Cancer||Phase 2|
|Recruiting||NCT02875626 - Role of Indocyanine Green (ICG) for Detection of Sentinel Nodes in Breast Cancer||N/A|
|Recruiting||NCT02934126 - The Development of a Personalized Decision Aid: Perspectives of Patients and Health Care Professionals on Shared Decision Making and Informational Needs on Radiotherapy for Breast Cancer||N/A|
|Recruiting||NCT02035085 - 19F Hot Spot MRI of Human Adipose-derived Stem Cells for Breast Reconstruction||Phase 1|
|Recruiting||NCT03080155 - A Study of the 3D MIRA System in Classifying Women at for Likelihood of Breast Cancer||N/A|
|Recruiting||NCT02840344 - Couples-Based Mindfulness for Young Breast Cancer Survivors||N/A|
|Recruiting||NCT02897635 - Integrative Approaches For Cancer Survivorship 2: Project 1||N/A|