Breast Cancer Clinical Trial
Official title:
Weight Loss Pilot Study in Postmenopausal Breast Cancer Survivors
The primary objective of this pilot study is to determine the effect of weight loss on a wide range of biomarkers associated with risk of breast cancer recurrence in overweight and obese breast cancer survivors. We hypothesized that weight loss would result in a statistically significant improvement in biomarkers associated with risk of breast cancer recurrence.
Women who are overweight, obese or gain weight after a breast cancer diagnosis are at greater
risk for recurrence and death compared with lighter women. There have been a few studies
examining the effects of different interventions on weight loss in breast cancer survivors
but very few have examined the effect of weight loss interventions on circulating levels of
markers associated with cancer risk. The overall objective of this proposal is to determine
how weight loss affects circulating levels of biomarkers associated with breast cancer risk
and recurrence, and quality of life of overweight and obese breast cancer survivors. The
central hypothesis is that weight loss will decrease the levels of markers adversely
associated with breast cancer and increase quality of life in these women. To test the
central hypothesis the following specific aims will be pursued:
- To assess the effects of two different weight loss interventions on biomarkers
associated with breast cancer risk and recurrence
- To assess the impact of the weight loss interventions on quality of life and sleep
- To assess the impact of weight loss on measures of bone health
;
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