Breast Cancer Clinical Trial
Official title:
Hypo-Fractionated Conformal Radiation Therapy to the Tumor Bed After Segmental Mastectomy
The purpose of this study is to determine whether high dose of radiation therapy (RT) are effective over standard 6-week radiation treatment in patients with breast cancer
Hypo-fractionation (several large fractions as the only radiation treatment) for breast
cancer irradiation was common in the forties and 50s and, while very successful in achieving
tumor control, was found to leave significantly inferior cosmetic results due to severe
fibrosis and telangiectasia compared to those obtained with multiple fraction regimens
(38-40). These complications were due to the use of very large fields, with the inclusion of
a large proportion of uninvolved skin and tissue surrounding the tumor.
Based on these assumptions, a few large fractions can be safely delivered to breast cancers
provided that 1) the target volume is sufficiently small and 2) the radiation technique
assures maximum sparing of the surrounding normal tissue. Conformal RT to the tumor bed of T1
breast cancers satisfies both requirements.
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