Breast Cancer Clinical Trial
Official title:
Pilot "Window of Opportunity" Neoadjuvant Study of Propranolol in Breast Cancer
This trial is a Phase II study using the "window-of-opportunity" design in which the treatment-free window between breast cancer diagnosis and surgical tumor resection is used to study the biological effects of the beta blocker propranolol .
- Patients will be recruited from the Garbar Breast Care Center and University Medical
Center following diagnosis of invasive breast cancer by breast biopsy.
- The sympatholytic nonselective beta blocker propranolol will be administered to all
participants in a non-randomized manner at an equal dose of 1.5 mg/kg/day.
- Following surgical resection of the tumor , the primary endpoint of this study is
quantified by comparing the proliferative index of the tumor before propranolol
administration (quantified using the initial tumor biopsy) and after 3 weeks of
propranolol (quantified using the surgically resected tumor).
- Additional molecular analyses and evaluation of safety and toxicity will also be
performed to better understand the effects of this treatment on breast cancers and
patient adherence to the drug.
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