Breast Cancer Clinical Trial
Official title:
An Early Phase Clinical Trial to Evaluate the Feasibility of CEST MRI in Patients With Early Stage Breast Cancer
Evaluate the feasibility of translating preclinical Chemical Exchange Saturation Transfer (CEST) MRI protocol designed to estimate tumor extracellular pH (pHe) to a clinical MRI scanner in women with early stage breast cancer. Assays are used to quantify tumor acidosis.
Those involved in the treatment of patients with breast cancer have pioneered the field of
personalized cancer therapy through the use of targeted therapies and their associated
biomarkers. Assays to quantify tumor acidosis and hypoxia are hypothesized to potentially
represent such biomarkers. However there is currently no gold standard for measuring either.
This trial will evaluate the feasibility of translating preclinical Chemical Exchange
Saturation Transfer (CEST) MRI protocol designed to estimate tumor extracellular pH (pHe),
to a clinical MRI scanner in women with early stage breast cancer. This trial will generate
preliminary data regarding the feasibility of this imaging technique. If successful, in
future studies CEST MRI may serve as an imaging biomarker for acidosis and hypoxia.
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Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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