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Collecting and Storing Tissue and DNA Samples From Patients Undergoing a Donor Stem Cell Transplant

Breast Cancer Clinical Trial

Official title:
Tissue Bank for Studies Related to Graft-Versus-Host Disease (GVHD)

Clinical Trial Summary

RATIONALE: Collecting and storing samples of blood, urine, and tissue from patients undergoing a donor stem cell transplant to test in the laboratory may help the study of graft-versus-host disease in the future.

PURPOSE: This research study is collecting and storing tissue and DNA samples from patients undergoing a donor stem cell transplant.

Clinical Trial Description

OBJECTIVES:

- To establish a DNA bank from donor and recipient (prior to transplant) peripheral blood for SNP studies.

- To establish a tissue bank for gene expression studies using donor and recipient (post-transplant) peripheral blood samples.

- To establish a tissue bank for proteomic studies using donor and recipient blood and urine samples.

- To establish a tissue bank for various studies using biopsy specimens.

- To establish a tissue bank for flow cytometric studies using recipient (post-transplant), and sample from stem cell product.

OUTLINE: Peripheral blood samples are collected from donors prior to stem cell mobilization and from patients prior to starting preparative regimen. Samples are studied by single nucleotide polymorphism (SNP) analysis, SNP array, proteomic analysis, gene expression, and other immunological laboratory methods. Blood, urine, and tissue samples are preserved for future studies. Extra skin biopsies and gastrointestinal biopsies are performed at diagnosis of graft-vs-host disease and preserved in a tissue bank for flow cytometric studies. ;

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

  • Breast Cancer
  • Chronic Myeloproliferative Disorders
  • Gestational Trophoblastic Disease
  • Gestational Trophoblastic Tumor
  • Graft Versus Host Disease
  • Graft vs Host Disease
  • Leukemia
  • Lymphoma
  • Multiple Myeloma
  • Multiple Myeloma and Plasma Cell Neoplasm
  • Myelodysplastic Syndromes
  • Myelodysplastic-Myeloproliferative Diseases
  • Myelodysplastic/Myeloproliferative Neoplasms
  • Myeloproliferative Disorders
  • Neoplasms
  • Neoplasms, Germ Cell and Embryonal
  • Neoplasms, Plasma Cell
  • Neuroblastoma
  • Ovarian Cancer
  • Plasmacytoma
  • Preleukemia
  • Testicular Germ Cell Tumor
  • Testicular Neoplasms
  • Trophoblastic Neoplasms
Clinical Trial Details
NCT number NCT00900406
Study type Observational
Source Vanderbilt-Ingram Cancer Center
Contact
Status Completed
Phase N/A
Start date January 2007
Completion date March 2010
View Details
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