MRI Characterization of Mammographically Detected DCIS

Breast Cancer, Stage 0 Clinical Trial

Official title: MRI Characterization of Mammographically Detected Calcifications and Ductal Carcinoma in Situ

Status Active, not recruiting

Clinical Trial Summary

This is a single institution, prospective observational clinical trial for women with mammographically identified calcifications that may represent ductal carcinoma in situ (DCIS). The purpose of this study is to determine whether quantitative, multiparametric breast MRI performed prior to surgical resection can biologically characterize this common pre-invasive malignancy, ductal carcinoma in situ (DCIS), which typically presents in asymptomatic women as suspicious calcifications on mammography.

Clinical Trial Description

The investigators will assess whether MRI signatures can determine which calcifications identified prior to surgical resection actually harbor DCIS, and whether these imaging features correlate with pathologic markers of proliferation (Ki-67) and inflammation (cox-2) within DCIS lesions. The investigators will also explore whether quantitative MRI features in the peri-tumoral region correlate with prognostic microenvironment markers of inflammation (TNFα) and angiogenesis (VEGF). Finally, investigators will assess whether a multivariate model using these markers can accurately predict risk of recurrence based on a multi-gene assay (Oncotype DX DCIS score). ;

Related Conditions & MeSH terms

• Breast Cancer, Stage 0
• Breast Carcinoma In Situ
• Carcinoma in Situ

• NCT number: NCT03495011
• Study type: Observational
• Source: University of Washington
• Status: Active, not recruiting
• Start date: April 20, 2018
• Completion date: April 2032