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Clinical Trial Summary

The objective of this protocol is to develop an institution-wide liquid biopsy protocol that will establish a common process for collecting blood and corresponding archived tumor specimens for future research studies at the University Health Network's Princess Margaret Cancer Centre. Circulating cell-free nucleic acids (cfNA), including cell-free DNA (cfDNA) and cell-free RNA (cfRNA), are non-invasive, real-time biomarkers that can provide diagnostic and prognostic information before cancer diagnosis, during cancer treatment, and at disease progression. Cancer research scientists and clinicians at the Princess Margaret are interested in incorporating the collection of peripheral blood samples ("liquid biopsies") into research protocols as a means of non-invasively assessing tumor progression and response to treatment at multiple time points during a patient's course of disease.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms

  • BRCA1 Mutation
  • BRCA2 Mutation
  • Breast Cancer
  • Cancer
  • Colon Cancer
  • Colorectal Neoplasms, Hereditary Nonpolyposis
  • Cowden Syndrome
  • Hamartoma Syndrome, Multiple
  • Head and Neck Cancer
  • Kidney Cancer
  • Leukemia
  • Lung Cancer
  • Lymphoma
  • Lynch Syndrome
  • Melanoma
  • Meningioma
  • Mutation
  • Myeloma
  • Ovarian Cancer
  • Syndrome
  • Uterine Cancer
  • Uterine Neoplasms

NCT number NCT03702309
Study type Observational
Source University Health Network, Toronto
Contact Celeste Yu, MSc
Phone 416-946-4501
Email Celeste.Yu@uhn.ca
Status Recruiting
Phase
Start date August 3, 2017
Completion date July 6, 2024

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