Brain Tumor Clinical Trial
Official title:
Investigation on the Pharmacokinetic and -Dynamic of Propofol During Awake Craniotomy
Certain kind of neurosurgical procedures require intraoperative alertness of the patient,
for example to perform speech tests during brain tumor resection. With respect to
anaesthesia, it is therefore required that the patient is asleep during the beginning and
the end of the procedure, however fully awake in between. To do so, the anaesthetic propofol
is used and an accurate knowledge of its pharmacokinetic and -dynamic (pk/pd) parameters is
required to optimally control anaesthesia. However, diverse pk/pd-parameter sets have been
described in the literature.
The aim of the study is to investigate whether the pk/pd model proposed by Marsh et al. or
by Schnider et al. more accurately describe the pk/pd of propofol during awake craniotomy.
n/a
Observational Model: Case-Only, Time Perspective: Prospective
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