Bowel Preparation Clinical Trial
Official title:
Safety and Efficacy of Low-volume Preparation in the Elderly: Oral Sulfate Solution vs 4L PEG Dolution
The investigators will investigate the safety and efficacy of low-volume preparation (Oral
Sulfate solution) compared to 4L PEG solution in bowel preparation before colonoscopy.
One aim of this study was to investigate the efficacy of low-volume preparation (Oral Sulfate
solution) on bowel preparation before colonoscopy.
Traditionally, polyethylene glycol (PEG) solution, which requires ingestion of a large volume
of liquid, has been used and now to a low-volume preparations because of its clear advantages
in tolerability. The tolerability of bowel preparations is related to their volume, taste,
and side effects, with this being a particular problem in the elderly. Meanwhile, a new oral
sulfate solution (OSS, SUPREP, Braintree Laboratories, Braintree, Mass) formulation as an
effective low-volume bowel cleansing agent, with a split-dose regimen was recently developed
in 2009.
Concerned about being able to better complete ingestion of bowel cleansing agent, OSS with
lower volume and improved taste features, as long as it does not sacrifice safety, shuld be a
better choice than PEG. Many studies have already looked at the efficacy and safety of OSS
compared to PEG in average risk population, but there are no data available in solely at the
elderly population. In this context, we hypothesized that OSS could be a good alternative to
a standard 4L-PEG solution in elderly patients.
In this report, we describe a multicenter, prospective, investigator-blind, randomized,
controlled trial investigating OSS with 4L PEG for efficacy and safety in the elderly.
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