Gene-activated Bone Substitute for Maxillofacial Bone Regeneration

Status Completed

Clinical Trial Summary

The purpose of this study is to evaluate the safety and efficacy of the gene-activated bone substitute consisting of octacalcium phosphate and plasmid DNA encoding vascular endothelial growth factor (VEGF) for maxillofacial bone regeneration. The patients with congenital and acquired maxillofacial bone defects and alveolar ridge atrophy will be enrolled.

Clinical Trial Description

All participants of the study will receive standard treatment according to the medical care standards for diseases and pathological conditions characterized by maxillofacial bone defects and/or alveolar ridge atrophy. Bone grafting procedures as part of the surgical treatment will be performed with the use of investigated medical device. The safety and efficacy of the implanted gene-activated bone substitute will be evaluated by clinical examination, comprehensive laboratory tests, and computer tomography within 6 months after surgery. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03076138
Study type	Interventional
Source	Histograft Co., Ltd.
Contact
Status	Completed
Phase	N/A
Start date	March 6, 2017
Completion date	December 14, 2018

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04043286` - The Effects of Dis/Reconnection of Implant Abutments on Peri-implant Bone Levels	N/A
Recruiting	`NCT03046147` - The Effect of Roux-en-Y Gastric Bypass on Bone Turnover	N/A
Completed	`NCT01292395` - Effects of Dietary Protein on Musculoskeletal Health During Calorie Deficiency	N/A
Completed	`NCT00485953` - Effect of Bisphosphonate on Bone Loss in Postmenopausal Women With Breast Cancer Initiating Aromatase Inhibitor Therapy	Phase 4
Completed	`NCT00674453` - The Prevention Of Postmenopausal Osteoporosis With Lasofoxifene And Cytokine Evaluation	Phase 2
Completed	`NCT00181584` - Zoledronic Acid to Prevent Bone Loss During Androgen Deprivation Therapy for Prostate Cancer	Phase 2
Withdrawn	`NCT04380155` - Cycling Duration and Bone Markers in in Active Young Adults	N/A
Active, not recruiting	`NCT04779216` - Effects of Romosozumab on Bone Density in Women With Anorexia Nervosa	Phase 3
Completed	`NCT05371418` - Comparative Clinical and Radiographical Evaluation of Treatment of Angular Bone Defect Related to Over Erupted Tooth Using GTR Followed by Orthodontic Intrusion Versus Orthodontic Intrusion Followed by GTR	N/A
Not yet recruiting	`NCT04345250` - Bone Response to Exercise and Energy Restriction in Young Adults	N/A
Recruiting	`NCT05405894` - Efficacy of Zoledronic Acid to Prevent Bone Loss Following Denosumab Discontinuation
Active, not recruiting	`NCT05301400` - Marginal Bone Loss in Single Implant Restaurations With Different Methods	N/A
Recruiting	`NCT04983758` - 20-year Implant Survival in Periodontally Healthy and Compromised Patients
Recruiting	`NCT04713774` - Bone Density and Vascular Calcifications Evolution After Renal Transplant
Completed	`NCT04279392` - Healthy Body, Healthy Bones After Bariatric Surgery Trial	Phase 1/Phase 2
Completed	`NCT04332679` - Non-resorbable Membranes Versus Titanium Meshes and Resorbable Membranes	N/A
Completed	`NCT05721014` - Effects of OsteoStrong vs. Individually Adapted and Combined Training on Bone Health	N/A
Recruiting	`NCT04883502` - Study of the Role of the Induced Membrane in the Reconstruction of Bone Loss in the Limbs
Not yet recruiting	`NCT05066815` - Evaluation of Crestal Bone Loss Around Short Dental Implants As Affected By Two Suprastructure Materials	N/A
Completed	`NCT03292146` - Effects of Denosumab on Bone Mineral Density in Women With Anorexia Nervosa: A Pilot Study	Phase 3