Obesity Clinical Trial
Official title:
The Effect of Moderate Alcohol Consumption on Subsequent Food Reward
Rationale
It has been shown in several studies that alcohol increases subsequent food intake. However,
moderate alcohol consumption has no clear effects on hunger and satiety hormones. In the
Western world, where palatable food is highly available, food reward may play an important
role in food intake. Alcohol consumption is known to stimulate neurotransmitters important
for food reward and may therefore stimulate the reward response on a subsequent meal. This
may lead to higher food consumption than when no alcohol is consumed. It is hypothesized
that the reward response of food or beverages can already be generated when food or
beverages are sensed in the mouth, because oral nutrient sensing is known to induce a
satiety response (i.e. the cephalic phase response). Moreover, taste buds directly signal
brain areas closely connected to the reward areas in the brain.
Primary objective
- To determine whether moderate alcohol consumption influences subsequent food reward, as
measured by questionnaires on food 'wanting' and food 'liking', and salivary and blood
parameters related to reward.
Secondary objectives
- To determine whether food reward is different when food is consumed than when food is
sensed in the mouth, as measured by questionnaires on food 'wanting' and food 'liking',
and salivary and blood parameters related to food reward.
- To determine whether moderate alcohol consumption influences subsequent food reward
differently when food is consumed than when food is sensed in the mouth, as measured by
questionnaires on food 'wanting' and food 'liking', and salivary and blood parameters
related to food reward.
n/a
Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Basic Science
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