Vasopressin Deficiency in Hemorrhagic Shock

Body Response to Trauma Clinical Trial

Official title:

Vasopressin Deficiency in Hemorrhagic Shock

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01107314
• Other study ID #: 2009-0528-H
• Secondary ID: A-13969.2
• Status: Completed
• Phase: N/A
• First received: April 19, 2010
• Last updated: January 12, 2018
• Start date: February 2010
• Est. completion date: April 30, 2011

Study information

• Verified date: March 2012
• Source: The University of Texas Health Science Center at San Antonio
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

In this study we hope to delineate the typical vasoactive mediator response of trauma patients to shock. We plan to assess serum levels of vasopressin and also catecholamines, angiotensin, and cortisol during resuscitation of trauma patients to delineate high risk populations for vasopressin deficiency.

Description:

This is a prospective observational study. The only research-driven procedure will be the removal of blood samples at designated time points(total blood removed 48 cc per patient). Hemodynamic, fluid infusion and agitation/pain data (RAMSEY Score) will prospectively be collected for research purposes. We will collect data from a convenience sample of patients (when research staff is available) over a one year period.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 81
• Est. completion date: April 30, 2011
• Est. primary completion date: April 30, 2011
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 98 Years

Eligibility

Inclusion Criteria:

• Patient is a male or female patient presumed to be at least 18 years of age;

• Patient has a reported or actual systolic blood pressure < 90 mmHg within 1 hour of arrival to the Emergency Room;

• Patient has clinical evidence of acute traumatic injury;

Exclusion Criteria:

• Patient is asystolic or requires CPR prior to arrival;

• Patient was transferred from an outside facility

• Patient known to be pregnant

• Patient known to be prisoner

Related Conditions & MeSH terms

• Body Response to Trauma
• Shock, Hemorrhagic

Intervention

Other:
• Phlebotomy
Blood draws (total 48 cc blood)

Locations

Country	Name	City	State
United States	UTHSCSA	San Antonio	Texas

Sponsors (1)

Lead Sponsor	Collaborator
The University of Texas Health Science Center at San Antonio

Country where clinical trial is conducted

United States,