Bile Duct Obstruction, Extrahepatic Clinical Trial
Official title:
Development of a New Immunochemistry Method Using Antibodies of Aminoacyl-tRNA Synthetases Group and Aminoacyl-transfer Ribonucleic Acid Synthetases-interacting Multifunctional protein2 Lacking Exon 2 in the Bile Duct Cancer Cell; Multicenter Study
The sensitivity of brushing cytology used to distinguish the cause of biliary strictures is low and clinical usefulness is not secured. The aim of this study was to develop a new differential staining method for cytology which is difficult to differentiate by the conventional staining method using biliary cancer related protein expressed only in bile duct cancer.
Hypothesis: The statistical significance of new staining method using aminoacyl-tRNA
synthetases (ARSs) group in normal bile duct cells and the bile duct cancer cells collected
by endoscopic retrograde pancreaticoduodenoscopy (ERCP) will be compared to prove the
usefulness of the new staining method.
Clinical study design: The bile duct cytology will be obtained by brushing cytology using
ERCP in patients with biliary stenosis. The expression of ARSs in the brushing cytology will
be evaluated by new staining method and compare with the results of conventional cytology
staining method including Papanicolaou staining. Immunofluorescence or immunohistochemistry
staining will be performed to differentiate the presence of the tumor. The sensitivity and
specificity of the new staining method will be compared with the conventional staining method
and its usefulness be confirmed.
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