Autism Spectrum Disorder Clinical Trial
Official title:
Patient-centric Model for Remote Management, Treatment and Rehabilitation of Children With Autism - Michelangelo / GOLIAH (Gaming Open Library for Intervention in Autism at Home) Project
To meet the required intensive intervention hour for treating children with autism spectrum disorder (ASD), the investigators developed an automated serious gaming platform (11 games) to deliver intensive intervention at home (GOLIAH). The major objective of the study is to test GOLIAH during a 6-month matched controlled exploratory study were to assess (1) the usefulness and acceptability of the gaming platform; (2) how experimental children performed using the different Imitation and JA games; and (3) whether children from the experimental group improved significantly more than children treated as usual (control group).
Background: To meet the required intensive intervention hour for treating children with
autism spectrum disorder (ASD), the investigators developed an automated serious gaming
platform (11 games) to deliver intensive intervention at home (GOLIAH) by mapping the
Imitation and Joint Attention (JA) subset of age-adapted stimuli from the Early Start Denver
Model (ESDM) intervention. For the purpose of this study, 24 ASD children will be recruited
(one half in Pisa and the other half in Paris). They will be divided into two groups: an
Experimental group (N=14) and a Control group (N=10). The Control group will not go through
the training sessions, they will participate only in the assessment sessions. All patients
will be referred to treatment as usual, according to local facilities.
The protocol is organized into 3 periods (with two assessments at T0 and T6).
- During the initial stage of the protocol (T0), all the ASD children (experimental
participants and controls) will be evaluated during a clinical session.
- During the rehabilitation period, only half of the children will participate in the
training sessions designed to improve their imitation and joint attention capacities.
- During the final stage of the protocol (T6), all children will be evaluated again
during a second clinical session.
The clinical assessments will occur at stage 0 and at stage 6. The same tools will be used
for these two assessments. The improvement of children's capabilities will be measured by
the progress made between stage 0 and stage 6. The investigators will be able to affirm that
the training was beneficial by comparing the clinical session performance between the
trained and control children.
;
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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