Atrial Fibrillation Clinical Trial
Official title:
Study of Concentrations of Amiodarone in Fat Tissue Obtained by Needle Aspiration in Patients on Chronic Treatment
The objective of this study is to determine if concentrations of amiodarone in fat tissue increases constantly over time during chronic treatment with this drug, and if blood concentrations reflect accurately the concentrations in fat tissue or not. This is because excessive concentrations of this drug in tissues can produce adverse effects.
Amiodarone is very effective to treat cardiac arrhythmias but its use is limited by its
toxicity, specially in chronic treatment. Accumulation of the drug in tissues is very
probably the cause of the majority of amiodarone delayed adverse effects. However, this has
not been proved because obtaining tissue samples is usually difficult and aggressive.
The investigators study, in patients following chronic treatment with amiodarone, if needle
aspiration can provide samples of fat tissue useful to accurately determine amiodarone
concentrations, how those concentrations in fat tissue correlate with cumulated dose, and
how concentrations in fat tissue correlate with concentrations in blood, which is easier to
obtain.
The investigators expect this knowledge will help to understand how amiodarone develops its
adverse effects and possibly lead to new ways of monitoring treatment with this drug, or to
adapt doses in chronic administration.
;
Allocation: Non-Randomized, Endpoint Classification: Pharmacokinetics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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