Atrial Fibrillation Clinical Trial
Official title:
A Prospective Randomised, Open Label, Blinded Endpoint (PROBE) Study to Evaluate DUAL Antithrombotic Therapy With Dabigatran Etexilate (110mg and 150mg b.i.d.) Plus Clopidogrel or Ticagrelor vs. Triple Therapy Strategy With Warfarin (INR 2.0 - 3.0) Plus Clopidogrel or Ticagrelor and Aspirin in Patients With Non Valvular Atrial Fibrillation (NVAF) That Have Undergone a Percutaneous Coronary Intervention (PCI) With Stenting
The main objective of this study is to compare a Dual Antithrombotic Therapy (DAT) regimen of
110mg dabigatran etexilate b.i.d. plus clopidogrel or ticagrelor (110mg dabigatran etexilate
(DE) DAT) and 150mg dabigatran etexilate b.i.d. plus clopidogrel or ticagrelor (150mg DE-DAT)
with a Triple Antithrombotic Therapy (TAT) combination of warfarin plus clopidogrel or
ticagrelor plus Aspirin (ASA) <= 100mg once daily (warfarin-TAT) in patients with Atrial
Fibrillation that undergo a PCI with stenting (elective or due to an Acute Coronary
Syndrome).
The study aims to show non-inferiority of each dose of DE-DAT when compared to Warfarin-TAT
in terms of safety. Safety will be determined by comparing the rates of bleeding events,
assessed using the modified International Society of Thrombosis and Haemostasis
classification of Major Bleeding and Clinically Relevant Non Major Bleeding Events.
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