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Clinical Trial Summary

This is a pilot investigator-blinded, randomized clinical trial to assess the feasibility of dupilumab treatment discontinuation or dose-reduction in children aged 1-17 years who have achieved sustained atopic dermatitis (AD) control on dupilumab.


Clinical Trial Description

Participants will be randomly assigned to one of three groups: discontinuation of dupilumab; reduction of dupilumab dose; or continuation of standard dupilumab dose. During the active study treatment period, participants will be asked to complete 5 study visits. At these visits, a physician will conduct a skin examination to assess atopic dermatitis (AD) severity and participants will complete questionnaires about their AD symptoms and severity. During the observational period, participants will be asked to complete questionnaires about their AD symptoms and medication use every twelve weeks, for a total of 3 follow-up contacts. The purpose of this study is to evaluate the feasibility and sustainability of reducing or discontinuing dupilumab in children with well-controlled AD. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06116526
Study type Interventional
Source Johns Hopkins University
Contact Hsing-Jou Su, MD
Phone 9292178030
Email hsu28@jh.edu
Status Recruiting
Phase Phase 4
Start date April 1, 2024
Completion date April 30, 2027

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