Atherosclerosis Clinical Trial
Official title:
Predictors of Coronary Artery Calcification in an African American Cohort
Coronary artery disease (CAD) is an important health concern for African Americans, who are diagnosed with CAD at high rates. Coronary artery calcification, which is characterized by calcium deposits in the coronary arteries, is a contributing factor to CAD. This study will examine the possible genetic causes of coronary artery calcification in African Americans.
In the United States, more people die from CAD than any other disease, with African
Americans, particularly women and young men, being more affected by CAD than European
Americans. One cause of CAD is atherosclerosis, a condition in which deposits of fat,
cholesterol, and other substances build up along the inner walls of arteries. Coronary
artery calcification occurs as a result of atherosclerosis and is characterized by calcium
build up in the arteries. Non-invasive imaging, including computed tomography (CT) scans, of
coronary artery calcification is an effective way to assess CAD risk. The Genetic
Epidemiology Network of Arteriopathy (GENOA) study, which is part of the Family Blood
Pressure Program (FBPP), is a study that examined siblings with high blood pressure during
two exams conducted between 1995 and 2004. The purpose of this new GENOA study, which will
enroll past GENOA participants, is to identify genetic factors that may lead to the
development of coronary artery calcification in African Americans. Conducting genetic
studies in the African American population will result in greater understanding of the
mechanisms of atherosclerosis, and may lead to improved strategies for the early
identification of people at risk for CAD and the development of new treatments for CAD.
This study will enroll people who have participated in the second GENOA exam and who live in
Jackson, Mississippi. Participants will attend one study visit at the University of
Mississippi Medical Center. During the study visit, participants will be interviewed by
study staff about their medical and family health history; health behaviors; physical
activity levels; and use of tobacco, alcohol, and medications. They will complete a walking
activity and tasks to assess memory, thinking speed, and accuracy. Participants will also
complete a questionnaire about their mood, a physical examination, a CT scan of the heart,
and a blood collection. A portion of blood will be stored for future research studies.
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Observational Model: Cohort, Time Perspective: Cross-Sectional
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