Atherosclerosis Clinical Trial
Official title:
Effect of Statins on Epigenetic Reprogramming of Monocytes in Patients With Elevated Levels of LDL
The innate immune system plays a pivotal role in the development and progression of
atherosclerosis. Recently, it was reported that monocytes can develop a long-lasting
immunological memory after stimulation with various microorganisms, which has been termed
'trained innate immunity'. This memory is induced by epigenetic reprogramming, in particular
trimethylation of lysine 4 at histone 3 (H3K4me3).
In this study, the investigators aim to investigate the immunophenotype of circulating
monocytes in patients with elevated LDL cholesterol levels and the effect of statins on this
phenotype.
The innate immune system plays a pivotal role in the development and progression of
atherosclerosis. Recently, it was reported that monocytes can develop a long-lasting
immunological memory after stimulation with various microorganisms, which has been termed
'trained innate immunity'. This memory is induced by epigenetic reprogramming, in particular
trimethylation of lysine 4 at histone 3 (H3K4me3).
The main objective is to study whether circulating monocytes of patients with elevated levels
of LDL have a phenotype of trained innate immunity compared to control patients. Subsequently
the investigators will study the effect of treatment with statins on the increased
inflammatory response and epigenetic changes of the innate immune system.
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