Asthma Clinical Trial
Official title:
The Effect of Vilanterol Against Methacholine-induced Bronchoconstriction in Mild Asthmatics
The study will assess the degree of bronchoprotection provided by the ultra long-acting beta2 agonist vilanterol against methacholine-induced bronchoconstriction.
This will be a double-blind, three-way crossover study comparing combination
vilanterol+fluticasone with fluticasone monotherapy and a placebo (vilanterol is not
available as a monotherapy). The order in which the treatments are given will be randomized
and each treatment will be separated by a minimum one-week washout. Fifteen asthmatic
participants will be recruited from the local community. Methacholine challenge testing (MCT)
with the two-minute tidal breathing protocol will be used to quantify the bronchoprotective
effects (if any) of each treatment against methacholine-induced bronchoconstriction.
Each participant will undergo a total of nine methacholine challenges. After a baseline
methacholine challenge, the randomized treatment (identity unknown to investigator or
participant) will be administered through an Ellipta® (multi-dose dry powder inhaler). Thirty
minutes following treatment administration, a second methacholine challenge will be
performed. At 24 hours post-treatment, each participant must re-visit the lab for one
methacholine challenge. The same process will be followed for each treatment.
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