Arrhythmia Clinical Trial
Official title:
Effects of Supplementation With Algal Triacylglycerols Versus Placebo on Heart Rate Variability in Elderly Patients
The purpose of this study is to test the hypothesis that dietary supplementation with an algal source of docosahexaenoic acid (DHA) can improve the heart rate variability in elderly patients.
In western countries, sudden cardiac death (SCD) represents the most common form of
cardiovascular death. SCD is often caused by ventricular arrhythmias in patients with a
known history of ischemic heart disease but it may also occurs in healthy persons.
In the last years has been extensively studied the protective role of long-chain n-3
polyunsaturated fatty acids (n-3 LCPUFA) against SCD both in healthy persons and in patients
affected by coronary artery disease.
The hypothesis that these evidences could be ascribed to an antiarrhythmic effect of n-3
LCPUFA, has been corroborated by the observation of a direct relationship between the
dietary intake of these nutrients and a better cardiac autonomic control.
This pathway, in particular, has been confirmed by the analysis of changes in heart rate
variability.
Most studies in this field used n-3 LCPUFA derived from fish oil, composed by a combination
of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). At our knowledge there are
few studies available evaluating the isolated role of DHA, derived from alternative sources
of n-3 LCPUFA, as the microalgae, in the prevention of fatal arrhythmias.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention
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