The Effects of Cricket- and Beef-derived Protein on Plasma Amino Acid Concentrations and Appetite Responses

Appetitive Behavior Clinical Trial

Official title:

The Effects of Dietary Protein Source on Postprandial Plasma Amino Acid Availability, Gut-derived Appetite Regulating Hormones, and Subjective Appetite Sensations in Young Males

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04719429
• Other study ID #: A08-M28-18B
• Status: Completed
• Phase: N/A
• Start date: January 28, 2019
• Est. completion date: April 9, 2019

Study information

• Verified date: January 2021
• Source: McGill University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Dietary protein plays an important role in appetite regulation. Source of ingested dietary protein may have different effects on appetite, satiety, and/or food intake in humans. Insects are a rich source of protein consumed by many people around the world; however, the capacity of insect-derived protein to regulate appetite and food intake is unclear. The purpose of this study was to compare postprandial plasma glucose, insulin, amino acid, and appetite regulatory hormone concentrations, subjective appetite sensations, and food intake following the ingestion of 25 g of cricket- and beef-derived protein in healthy young males.

Description:

With the rapid increase in the global population, the production of sufficient amounts of conventional animal-based protein to meet global dietary demands may no longer be desired nor feasible. Insects may represent an environmentally sustainable additional source of dietary protein that has the potential to help ensure global food security in the future. However, the functional characteristics of insect-derived proteins when fed to humans is unclear. Further, how insect-derived proteins compare to other animal-derived proteins (e.g. from beef) have not been explored.

The purpose of this study was to compare postprandial plasma glucose, insulin, and amino acid concentrations, gut-derived appetite regulatory hormones, subjective appetite sensations, and ad libitum energy intake following the ingestion of 25 g insect- or beef-derived protein in healthy young men. It was hypothesized that hyperaminoacidaemia would be more rapid following the ingestion of beef-derived protein compared to cricket-derived protein, although total amino acid availability would be similar between protein sources over a 300-minute postprandial period. It was further hypothesized there would be no difference between protein sources on postprandial subjective appetite sensations or subsequent ad libitum energy intake.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 20
• Est. completion date: April 9, 2019
• Est. primary completion date: April 9, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 35 Years

Eligibility

Inclusion Criteria:

• Male

• Aged between 18-35 years inclusive

• Healthy, moderately active

• BMI < 30 kg/m2 and > 18.5 kg/m2

• Having given informed consent

Exclusion Criteria:

• Presence of any identified metabolic or intestinal disorders

• Use of tobacco products

• Adherence to a strict vegetarian or vegan diet

• Use of medications known to affect protein metabolism

• Allergy to shellfish or crustaceans

• Allergy to beef protein

• Engagement in physical exercise training more than 6 days per week

Related Conditions & MeSH terms

• Aminoacidemia
• Appetitive Behavior

Intervention

Dietary Supplement:
• Cricket-derived Protein
Beverage containing 25 g cricket-derived protein
• Beef-derived Protein
Beverage containing 25 g beef-derived protein

Locations

Country	Name	City	State
Canada	Exercise Metabolism and Nutrition Research Laboratory	Montreal	Quebec

Sponsors (1)

Lead Sponsor	Collaborator
McGill University

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Plasma leucine concentration	umol/L	0-5 hours in the post-prandial period
Primary	Subjective appetite sensations (hunger, fullness, desire to eat, prospective food consumption)	mm (visual analogue scale)	0-5 hours in the post-prandial period
Secondary	Plasma branched-chain amino acid concentration	umol/L	0-5 hours in the post-prandial period
Secondary	Plasma essential amino acid concentration	umol/L	0-5 hours in the post-prandial period
Secondary	Plasma non-essential amino acid concentration	umol/L	0-5 hours in the post-prandial period
Secondary	Plasma total amino acid concentration	umol/L	0-5 hours in the post-prandial period
Secondary	Plasma glucose	mmol/L	0-5 hours in the post-prandial period
Secondary	Plasma insulin	pmol/L	0-5 hours in the post-prandial period
Secondary	Plasma GLP-1	pg/mL	0-5 hours in the post-prandial period
Secondary	Plasma PYY	pg/mL	0-5 hours in the post-prandial period
Secondary	Ad libitum food energy intake	kJ	assessed 5 hours after protein intake