Role of CBD in Regulating Meal Time Anxiety in Anorexia Nervosa

Status Recruiting

Clinical Trial Summary

No studies of cannabidiol (CBD) have focused on Anorexia Nervosa (AN). Dose, side effects, tolerability, acceptability of pure CBD in AN must be established. The current study is an important first step in the investigation of CBD for AN. Cannabis products have been recently legalized in many states, and CBD in particular has been shown to reduce anxiety. Therefore, CBD may represent a promising new treatment for AN. The endocannabinoid system is involved in the regulation of functions relevant to eating disorders. Furthermore, data suggest that eating disorders are associated with alterations of the endocannabinoid system. Prior attempts to target the endocannabinoid system in AN have focused on CB1 receptor agonists that can increase anxiety. Moreover, CBD may be particularly beneficial in decreasing anxiety in AN via its action at serotonin receptors. Lastly, the impact of CBD on eating behavior and weight in AN must be determined. The current study seeks to explore these hypotheses using the aims in the following section.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04878627
Study type	Interventional
Source	University of California, San Diego
Contact	Megan E Shott, BS
Phone	858-246-5272
Email	mshott@health.ucsd.edu
Status	Recruiting
Phase	Early Phase 1
Start date	January 20, 2022
Completion date	October 2024

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05531604` - Appetitive Conditioning in Anorexia Nervosa
Enrolling by invitation	`NCT04174703` - Preparing for Eating Disorders Treatment Through Compassionate Letter-Writing	N/A
Active, not recruiting	`NCT04883554` - Impact of an Olfactory Sensory Therapeutic Group for Adolescent Patients With Restrictive Anorexia Nervosa , Pilot Study	N/A
Recruiting	`NCT04213820` - TMS and Body Image Treatment for Anorexia Nervosa	N/A
Completed	`NCT03414112` - The Impact of Oxytocin on the Neurobiology of Anorexia Nervosa	Early Phase 1
Recruiting	`NCT06144905` - Norwegian Microbiota Study in Anorexia Nervosa
Recruiting	`NCT05803707` - Home-based Adapted Physical Activity in Anorexia Nervosa: a Feasibility Pilot Study	N/A
Recruiting	`NCT05682417` - Impact of Body Schema Distortion on Remission and Weight Regain in Anorexia Nervosa	N/A
Not yet recruiting	`NCT06380257` - Anorexia Nervosa and Brain in Adolescence
Not yet recruiting	`NCT04804800` - Virtual Reality Place in the Management of Body Dysmorphia Disorders in Anorexia Nervosa	N/A
Not yet recruiting	`NCT03600610` - Evaluation of CARdiac Abnormalities by Echocardiography and MRI in Malnourished Patients Suffering From Anorexia Nervosa	N/A
Completed	`NCT02745067` - Effectiveness of Enhanced Cognitive Behavioral Therapy (CBT-E) in the Treatment of Anorexia Nervosa	N/A
Completed	`NCT02382055` - Changing Habits in Anorexia Nervosa: Novel Treatment Development	N/A
Completed	`NCT03075371` - Homeostatic and Non-homeostatic Processing of Food Cues in Anorexia Nervosa	N/A
Terminated	`NCT02240797` - Kappa Opioid Receptor Imaging in Anorexia	N/A
Completed	`NCT03144986` - Insula-coil Deep TMS for Treatment Resistant Anorexia Nervosa	N/A
Unknown status	`NCT01761942` - Fatty Acids Omega -3 Diet Supplementation Efficiency and Safety Evaluation in Anorexia Nervosa	Phase 2
Completed	`NCT02551445` - A fMRI Pilot Study of the Effects of Meal-support in Eating Disorders.	N/A
Completed	`NCT01579682` - Adaptive Family Treatment for Adolescent Anorexia Nervosa	N/A
Completed	`NCT00946816` - The Effects of Dietary Intervention on Gastrointestinal Function in Patients With Anorexia Nervosa and Obesity	N/A