Incomplete Total Body Protein Recovery in Adolescent Patients With Anorexia Nervosa

Anorexia Nervosa Clinical Trial

Official title: Incomplete Total Body Protein Recovery in Adolescent Patients With Anorexia Nervosa

Status Completed

Clinical Trial Summary

The study aimed to assess protein accretion during weight gain in adolescent patients with Anorexia nervosa

Clinical Trial Description

Background: Bone health and growth during adolescence require adequate Total Body Protein (TBPr). Re-nutrition for patients with anorexia nervosa (AN) should aim to normalize body composition, i.e. recovery of fat mass and TBPr.

Objective: The study intended to analyze predictors of protein status, including exercise status, in adolescents with AN, and to investigate whether weight gain would replete body protein deficits.

Methods: The investigators assessed TBPr in a longitudinal, observational study as height-adjusted nitrogen index (NI) using in-vivo neutron activation analysis in adolescents with AN at the commencement of refeeding (T0), as well as seven months thereafter (T1), and in age-matched normal weight controls. Lean tissue and fat mass were assessed with Dual-Energy X-Ray Absorptiometry (DXA). BMI, BMI-SDS and lean tissue mass were tested as predictors of protein status using Receiver Operating Characteristic (ROC) analysis. ;

Related Conditions & MeSH terms

• Anorexia
• Anorexia Nervosa

• NCT number: NCT03334032
• Study type: Observational
• Source: Charite University, Berlin, Germany
• Status: Completed
• Phase: N/A
• Start date: July 2004
• Completion date: July 2010