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Clinical Trial Summary

Maternal hypotension after spinal anesthesia in parturients undergoing cesarean section is a very common problem leading to several complications to both patients and their babies. It can cause maternal discomfort, lightheadedness, nausea and vomiting. The most important complication is the decreasing blood flow to babies; which may lead to fetal acidosis.

Many interventions has been studied in order to prevent hypotension after spinal anesthesia in cesarean section e.g., fluid loading: colloid vs crystalloid, medications: ephedrine, phenylephrine, and metaraminol, etc. The recent study showed ondansetron (the antiemetic drug) can be effectively used to prevent hypotension after spinal anesthesia in normal patients or parturients. The action of ondansetron is believed to inhibit Bezold-Jarish reflex.

This aim of this study is to compare the efficacy of ephedrine and ondansetron in the prevention of maternal hypotension after spinal anesthesia in cesarean section.


Clinical Trial Description

n/a


Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Prevention


Related Conditions & MeSH terms

  • Anesthesia; Adverse Effect, Spinal and Epidural
  • Hypotension

NCT number NCT02194192
Study type Interventional
Source Mahidol University
Contact
Status Completed
Phase N/A
Start date July 2014
Completion date March 2015

See also
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Completed NCT01741610 - Fluid Coloading and the Incidence of Hypotension Phase 4
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Completed NCT03541798 - Comparison of Three Different Sitting Positions for Performing Combined Spinal-Epidural Anesthesia N/A
Recruiting NCT02393196 - Colloid Preload Versus Colloid Coload During Cesarean Deliveries Phase 4
Not yet recruiting NCT04703088 - ONDANSETRON AND EFFECTIVE DOSE IN 50% OF SUBJECTS OF PROPHYLACTIC NOREPINEPHRINE INFUSIONS FOR PREVENTING SPINAL ANESTHESIA-INDUCED HYPOTENSION DURING CESAREAN DELIVERY Phase 3
Completed NCT01845389 - Comparative Study Between Continuous Epidural Anesthesia And Continuous Spinal Anesthesia Using Wiley™ Spinal Catheter N/A
Completed NCT02477501 - Ephedrine vs. Nor Epinephrine Infusion in Preventing Hypotension After Spinal Anesthesia for Cesarean Section Phase 4
Terminated NCT01877356 - Comparative Study Between Bilateral and Unilateral Spinal Anaesthesia N/A
Recruiting NCT03293472 - Neurotoxicity of Spinal Anesthesia With Ropivacaine and Bupivacaine Phase 4