Polymorphism of ApoE in Alzheimer's Disease: Genetic Study in Castile and Leon (Spain)

Alzheimer Disease Clinical Trial

Official title: Alzheimer's Disease as a Sociosanitary Priority: ApoE Gene Polymorphism

Status Completed

Clinical Trial Summary

The general objective of this randomized and longitudinal clinical study was to estimate the frequencies of ApoE variants both in the user population of the "Messengers of Peace" Residences and the "Associations of Relatives of Alzheimer's Patients" in Castile y Leon, since, due to its geographical location at the crossroads, it has received multiple genetic contributions from both northern Europe, the Mediterranean area and northern Africa.

The main questions it aims to answer are:

• What are the allelic frequencies of ApoE variants in the population of individuals with Alzheimer's disease in Castile and Leon?

• Is there a correlation between the ApoE4 variant and the lipid profile in the blood of individuals with Alzheimer's disease in this region?

Clinical Trial Description

In the context of Alzheimer disease research, it is widely recognized that the ApoE gene plays a fundamental role in the genetic predisposition of this disease. With three major alleles: ApoE2, ApoE3, and ApoE4, genetic variability in the ApoE gene has been the subject of extensive attention in previous research and its association with increased risk of Alzheimer's disease has remained consistent. Within this framework, three hypotheses are proposed focused on understanding the specific influence of ApoE on Alzheimer's disease and exploring the possible underlying mechanisms.

Within this framework, three hypotheses are proposed focused on understanding the specific influence of ApoE on Alzheimer disease and exploring the possible underlying mechanisms:

1. - Research hypotheses: The genetic variant ApoE4/4 is significantly related to a higher risk of developing Alzheimer's disease compared to individuals who do not carry this genotype.

2. - Research hypotheses: The ApoE2/2 genetic variant is associated with a lower risk of developing Alzheimer's disease compared to other genotypes.

3. - Research hypotheses: People who carry the ApoE4 isoform have elevated levels of total cholesterol and LDL-cholesterol. ;

Related Conditions & MeSH terms

• Alzheimer Disease

• NCT number: NCT06275243
• Study type: Interventional
• Source: Universidad de León
• Status: Completed
• Phase: N/A
• Start date: July 6, 2022
• Completion date: March 22, 2024