Alzheimer Disease Clinical Trial
Official title:
Comparisons of gaIt aNalyses pERformance Between the Gaitrite walkwaYs
The GAITRite® system is an instrumented with resistive pressure sensors gait analyzer. It was
first validate in 2001 against paper-and-pencil (intraclass correlation coefficient [ICC] >
95%) for spatial measures and against video-based (ICC > 93%) for temporal measures, and was
thus a reliable tools to measure step lengths and times in both walkway center and
left-of-center measurements. It was considered as one of the gold standards in gait analyses.
This gait analyze system may distinguish prospectively faller and non-faller older adults,
but it can detect spatial, temporal, and spatiotemporal measures of gait and greater
variability of gait parameters which were associated with and predictive of both global- and
domain-specific cognitive decline. Moreover, spatiotemporal gait parameters analyzed using
GAITRite® were more disturbed in the advanced stages of dementia, and more affected in the
non-AD dementia than in AD suggesting that quantitative gait parameters could be used as a
surrogate marker for improving the diagnosis of dementia.
Nevertheless, GAITRite® is not a unique system and it comprises different walkways. One of
these technologies was a roll-up system (platinum plus classic, RE, Basic and Safari), and
the other was a system composed by a changeable association of plates (CIRFACE). In order to
ensure a good comparability between studies using these different walkways, it appears
important to compare the performances of these walkways in gait analysis. Thus, the main aim
of this study was to compare the performances in gait analyze between the GAITRite® platinum
plus classic and the GAITRite® CIRFACE among older adults. Secondary aims were to compare
these parameters among patients with cognitive complaint, minor or major neurocognitive
disorder (NCD) related to Alzheimer disease.
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