Clinical Trials Logo

Clinical Trial Summary

One of the major challenges in adapting to high altitudes is that with increasing altitude sleeping quality declines rapidly. Thus, the night sleep can only provide limited to none regeneration. It usually takes a prolonged stay at a constant altitude to adapt sufficiently to the altitude and to have a refreshing night sleep. 1975 Reit et. al showed in their EEG-recordings that the sleep architecture (the regular succession of the particular sleep phases) is disturbed by repeating arousals which occur due to an irregularity in the breathing rhythm.

The purpose of this study is to create a better understanding of the underlying mechanisms that lead to failed acclimatization and AMS, due to sleep disturbance.


Clinical Trial Description

Under sea level conditions humans breath between 10 and 12 times per minute. The breathing cycle in high altitude is accelerated. If the conscious breathing control vanishes during sleep a periodic breathing with alternating episodes of hyperventilation and apnea is the result. This circumstance causes repetitive arousals that do not allow a normal sleep pattern. The associated adverse effects are fatigue, slow or failed acclimatization, weakening of the immune system, lack of motivation and the disability to make rational decisions.

Sleep deprivation is a common reason for the abortion of a trip, accidents and severe forms of Acute Mountain Sickness (AMS). ;


Study Design

Observational Model: Cohort, Time Perspective: Prospective


Related Conditions & MeSH terms


NCT number NCT01465971
Study type Observational
Source Goethe University
Contact
Status Completed
Phase N/A
Start date May 2011
Completion date December 2011

See also
  Status Clinical Trial Phase
Completed NCT01199042 - Bipap autoSV Advanced in Central Apnea Patients N/A
Completed NCT01426776 - Effect of Heart Valve Replacement on Cheyne-Stokes Respiration N/A
Completed NCT01175031 - Comparison of Breathing Event Detection by a Continuous Positive Airway Pressure Device to Clinical Polysomnography N/A
Completed NCT00909259 - Feasibility Study to Determine the Effects of Phrenic Nerve Stimulation in Patients With Periodic Breathing Phase 1
Terminated NCT00694720 - Evaluation of the Effect of AVE0657 in Cheynes-Stokes Breathing Syndrome Patients Phase 2
Completed NCT01037439 - Comparison of Modified With Conventional Adaptive Servoventilation Processes N/A
Completed NCT00495196 - Cardiovascular Responses in Congestive Heart Failure With Cheyne- Stokes Respiration N/A
Terminated NCT03085641 - Treatment of Central Sleep Apnoea in Patients With Heart Failure With Nasal High Flow Therapy (nHFT) N/A
Completed NCT03421704 - A Prospective Multicenter Registry of Patients With Sleep Disordered Breathing Treated With DreamStation BiPAP autoSV.
Completed NCT00543452 - Effect of Oxygen on Core Temperature N/A
Completed NCT02034175 - Comparison of SomnaPatch With Polysomnography in Sleep Disordered Breathing N/A
Recruiting NCT01212705 - Effect of Adaptive Servoventilation on Cardiac Function in Chronic Heart Failure and Cheyne-Stokes Respiration N/A