[C-11]PiB PET Imaging in Alcohol Use Disorders

Status Completed

Clinical Trial Summary

To determine whether alcoholics (AUD) have a greater rate of amyloid positivity (ABeta+) compared to an age-matched cognitively normal control group (HC).

Clinical Trial Description

There is a long-established relationship between alcohol use disorders (AUD), cognitive impairments, and the development of dementia. Some, but not all basic data suggest that alcohol abuse can alter the expression of amyloid precursor protein, and the enzymes that process it. Thus, there is a need for in vivo PET studies to further investigate the relationship between AUD and AD and the mechanism through which alcohol abuse exerts its effect on this type of dementia. Here, we propose to use the amyloid Beta (ABeta) radiotracer carbon-11 labeled Pittsburgh Compound-B ([C-11]PiB) and PET (Klunk et al., 2004) to determine whether AUD increase the risk to be brain ABeta+ in middle aged adults. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03746366
Study type	Interventional
Source	University of Pittsburgh
Contact
Status	Completed
Phase	Early Phase 1
Start date	December 1, 2018
Completion date	July 1, 2020

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