Effect of Age and Fitness on Vascular Function and Oxidative Stress During Acute Inflammation

Aging Clinical Trial

Official title: Effect of Age and Fitness on Vascular Function and Oxidative Stress During Acute Inflammation

Status Terminated

Clinical Trial Summary

This study focuses on whether high cardiorespiratory fitness in older adults has a protective effect on the vascular response to acute inflammation in comparison to low-fit older and young adults.

Clinical Trial Description

Acute and chronic inflammation both increase cardiovascular disease risk, especially with aging, which may be due to vascular dysfunction. Aging and inflammation also lead to increased oxidative stress, which impairs vascular function. During acute inflammation, endothelial function is altered differently in younger and older adults with decreases in endothelial function in younger, but not older adults. However, cardiorespiratory fitness is cardio-protective, impacting inflammation, vascular function, and oxidative stress. During acute inflammation, moderately fit older adults exhibit similar responses to younger adults, suggesting preserved endothelial reactivity. However, whether the protective mechanism is oxidative stress has not been confirmed. Furthermore, it is undetermined whether the vascular dysfunction is further propagated down the arterial tree during acute inflammation to the microvasculature.

The aims of this research study are to determine if age and fitness moderate the vascular response to acute inflammation and to determine if antioxidant administration eliminates vascular dysfunction during acute inflammation. The results from this study will help to elucidate if fitness is a protective and preventive measure to ameliorate the detrimental cardiovascular response to acute inflammation. Thus, this study may provide health professionals with a behavioral intervention to reduce cardiovascular disease burden in the rapidly growing aging population. ;

Related Conditions & MeSH terms

• Aging
• Inflammation

• NCT number: NCT03889158
• Study type: Interventional
• Source: University of Illinois at Chicago
• Status: Terminated
• Phase: Phase 4
• Start date: March 25, 2019
• Completion date: March 13, 2020