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Manta Study: Avastin Versus Lucentis in Age Related Macular Degeneration — MANTA  

Age Related Macular Degeneration Clinical Trial

Official title:
A Randomized Observer and Subject Masked Trial Comparing the Visual Outcome After Treatment With Ranibizumab or Bevacizumab in Patients With Neovascular Age-related Macular Degeneration Multicenter Anti VEGF Trial in Austria (MANTA)

Clinical Trial Summary

Angiogenesis plays a key role in the development of choroidal neovascularizations (CNV) in age-related macular degeneration. Vascular endothelial growth factor (VEGF) is the most important factor involved in this angiogenetic processes in the eye. This forms the basis for new therapeutic interventions in exudative AMD. Currently two drugs have been approved by the FDA and one drug is used off-label. All these drugs are administered intravitreally. The present study aims to directly compare the effects ranibizumab and bevacizumab in a randomized controlled study in patients with neovascular AMD.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00710229
Study type Interventional
Source The Ludwig Boltzmann Institute of Retinology and Biomicroscopic Laser Surgery
Contact Ilse Krebs, MD
Phone 43-17-1165
Email Ilse.Krebs@wienkav.at
Status Recruiting
Phase Phase 3
Start date July 2008
View Details
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