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Oral Thalidomide and Tegafur-uracil to Decrease Hepatocellular Carcinoma Recurrence

Recurrent Hepatocellular Carcinoma Clinical Trial

Official title:
Oral Thalidomide and Tegafur-uracil to Decrease Hepatocellular Carcinoma Recurrent After Hepatectomy in High Risk Patients -A Phase II Study

Clinical Trial Summary

This single-centered phase II clinical study is to obtain preliminary information on 1-year recurrence-free survival rate, recurrence-free survival and safety profile of thalidomide in combination with tegafur-uracil in hepatocellular carcinoma after hepatectomy and explore biomarkers(VEGF/bFGF) for thalidomide response.

Clinical Trial Description

After liver resection to remove the hepatocellular carcinioma completely, the patients with high risk of tumor recurrence will be enrolled into this study. The high risk of tumor recurrence depends on tumor characteristics. The risk factors of tumor characteristics included tumor size >5 cm in diameter, abscence of encapsulation, vascular invasion and presence of daughter nodules. The patients with high risk of tumor recurrence will have 1 to 3 risk factors. When the patients are enrolled into the study, oral thalidomide in combination with tegafur-uracil will be applied to prevent tumor recurrence. The patients will be fillowed uo erevy 3 mnoths. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02447679
Study type Interventional
Source Chang Gung Memorial Hospital
Contact
Status Completed
Phase Phase 2
Start date August 2010
Completion date February 2, 2017
View Details
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