Depression Clinical Trial
Official title:
A Randomized Double-blind Placebo-controlled Trial to Working Memory Training in Substance Abusers
Background: Substance abusers show impaired working memory (WM) functioning. Promising
findings show training WM results in an improved working memory capacity (WMC) and a
decrease of clinical symptoms in a range of disorders, including alcohol addiction.
Aim: To test the effect of a WM training in addition to treatment as usual (TAU) on
substance use, craving, WMC, impulsivity, attention bias and psychopathology.
Design: A randomized double-blind placebo-controlled trial with a parallel group design. The
WM training adapted to participants' WMC whereas the placebo training consisted of
non-adaptive easy versions of these tasks.
Setting: Two departments of an addiction treatment clinic in Rotterdam, the Netherlands.
Participants: 120 inpatients diagnosed with an alcohol, cannabis or cocaine dependency who
were in treatment as usual .
Measurements: Primary outcome measures: Substance use and craving. Secondary outcome
measures: WMC, impulsivity, attention bias and psychopathology. Participants were assessed
before and after 24 sessions of WM training as well as two months after the training.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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