Which Factors Influence the Duration & the Success of Mechanical

Status Completed

Clinical Trial Summary

This study aims to identify factors influencing the time span and success of reperfusion after a mechanical thrombectomy in the acute phase of cerebral infarction, and in particular the effect of intra-venous thrombolysis.

Clinical Trial Description

Mechanical thrombectomy (MT), associated with standard IV thrombolysis (IVT) treatment, is effective during the acute phase of cerebral infarction with proximal occlusion of the anterior circulation in reducing disability at three months. MT-only treatment has only been assessed retrospectively in subgroups of controlled studies, with a significant difference in favour of the treatment. These results have led to a discussion about the benefits of MT without IVT in cases of proximal occlusion or carotid terminus occlusion. Recent data are in favour of a better prognosis for patients benefiting from a combined procedure. The impact of IVT on the implementation of MT is widely disputed, in particular the speed of execution, which could be enhanced by IVT. The factors influencing the time span and success of reperfusion after an MT are still not well-known, IVT in particular. The investigators have made the assumption that IVT could have an effect on the success of MT by shortening the duration of the procedure and increasing the likelihood of satisfactory revascularisation.

The investigators carried out a retrospective study based on data gathered prospectively by the Franche-Comté Stroke Registry. The investigators also considered other factors which could have affected the duration of the procedure or the rate of satisfactory revascularisation, including location of infarct, thrombus size and stroke aetiology.

Hypothesis: the investigators have made the assumption that IVT could have an effect on the success of MT by shortening the duration of the procedure and increasing the likelihood of satisfactory revascularisation. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03451903
Study type	Observational
Source	Centre Hospitalier Universitaire de Besancon
Contact
Status	Completed
Phase
Start date	January 1, 2015
Completion date	February 1, 2018

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03281590` - Stroke and Cerebrovascular Diseases Registry
Enrolling by invitation	`NCT06074081` - Comparison of 4-weeks of Motor Relearning Program and Mirror Therapy in Improving Upper Limb Motor Function in Stroke Patients.	N/A
Terminated	`NCT04039178` - Efficacy of EMF BCI Based Device on Acute Stroke	N/A
Completed	`NCT04521634` - Glycaemic Variability in Acute Stroke
Completed	`NCT03477188` - The Effects of Somatosensory and Vestibular Rehabilitation Additional Conventional Therapy on Balance in Patients With Acute Stroke.	N/A
Recruiting	`NCT05065216` - Treatment of Acute Ischemic Stroke (ReMEDy2 Trial)	Phase 2/Phase 3
Recruiting	`NCT02677415` - Impact of Anesthesia Type on Outcome in Patients With Acute Ischemic Stroke (AIS) Undergoing Endovascular Treatment	N/A
Recruiting	`NCT01541163` - Heart and Ischemic STrOke Relationship studY	N/A
Completed	`NCT01210729` - Mechanical Recanalization With Flow Restoration in Acute Ischemic Stroke	Phase 2
Recruiting	`NCT00785343` - Study of Robot-assisted Arm Therapy for Acute Stroke Patients	Phase 1
Completed	`NCT04779710` - How Does Dysphagia Assessment in Acute Stroke Affect Pneumonia?
Active, not recruiting	`NCT03635749` - Intensive Medical Therapy for High-risk Intracranial or Extracranial Atherosclerosis	Phase 3
Recruiting	`NCT06149754` - BraiN20® Monitoring in Acute Stroke Undergoing Thrombectomy
Recruiting	`NCT04491695` - Tirofiban for the Prevention of Neurological Deterioration in Acute Ischemic Stroke	Phase 2/Phase 3
Recruiting	`NCT04283760` - Investigation of the Reliability and Validity of the Movement Imagination Questionnaire - Revised Second in Acute Stroke Patients
Recruiting	`NCT05454397` - A Study on the Status of Nutritional Risk Screening and Nutritional Therapy in Neurology Hospitalized Stroke Patients
Completed	`NCT04488692` - Early Functional Training in Acute Stroke Inpatient Ward	N/A
Recruiting	`NCT04214522` - Reliability and Validity of the Kinesthetic and Visual Imagery Questionnaire in Acute Stroke Patients
Not yet recruiting	`NCT04157231` - Essential Acute Stroke Care in Low Resource Settings: a Pilot studY	N/A
Recruiting	`NCT05469438` - IMAS Optimization and Applicability in an Acute Stroke Setting.

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Which Factors Influence the Duration and the Success of Mechanical Thrombectomy During the Acute Phase of Cerebral Infarction? — REPAIR-FC

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms