Donepezil Trial for Motor Recovery in Acute Stroke

Status Withdrawn

Clinical Trial Summary

AIMS: To establish: 1) whether motor deficits in acute stroke improve more in patients taking donepezil, relative to placebo, for 12 weeks; 2) whether brain functional MRI changes as a result of donepezil after 12 weeks.

Clinical Trial Description

Stroke is a major personal and social burden, being the commonest cause of severe adult disability. Recovery has been shown in animal models to be dependent upon adequate levels of acetylcholine within the brain - which in stroke is likely to be deficient. This is because acetylcholine-producing nerve cells in the brain are often damaged by strokes. Consequently, the investigators hypothesise that recovery may be improved by boosting acetylcholine levels in the brain - that can be readily achieved by treating with donepezil. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01442766
Study type	Interventional
Source	Imperial College London
Contact
Status	Withdrawn
Phase	Phase 1/Phase 2
Start date	November 2011
Completion date	May 2014

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03281590` - Stroke and Cerebrovascular Diseases Registry
Enrolling by invitation	`NCT06074081` - Comparison of 4-weeks of Motor Relearning Program and Mirror Therapy in Improving Upper Limb Motor Function in Stroke Patients.	N/A
Terminated	`NCT04039178` - Efficacy of EMF BCI Based Device on Acute Stroke	N/A
Completed	`NCT04521634` - Glycaemic Variability in Acute Stroke
Completed	`NCT03477188` - The Effects of Somatosensory and Vestibular Rehabilitation Additional Conventional Therapy on Balance in Patients With Acute Stroke.	N/A
Recruiting	`NCT05065216` - Treatment of Acute Ischemic Stroke (ReMEDy2 Trial)	Phase 2/Phase 3
Recruiting	`NCT02677415` - Impact of Anesthesia Type on Outcome in Patients With Acute Ischemic Stroke (AIS) Undergoing Endovascular Treatment	N/A
Recruiting	`NCT01541163` - Heart and Ischemic STrOke Relationship studY	N/A
Completed	`NCT01210729` - Mechanical Recanalization With Flow Restoration in Acute Ischemic Stroke	Phase 2
Recruiting	`NCT00785343` - Study of Robot-assisted Arm Therapy for Acute Stroke Patients	Phase 1
Completed	`NCT04779710` - How Does Dysphagia Assessment in Acute Stroke Affect Pneumonia?
Active, not recruiting	`NCT03635749` - Intensive Medical Therapy for High-risk Intracranial or Extracranial Atherosclerosis	Phase 3
Recruiting	`NCT06149754` - BraiN20® Monitoring in Acute Stroke Undergoing Thrombectomy
Recruiting	`NCT04491695` - Tirofiban for the Prevention of Neurological Deterioration in Acute Ischemic Stroke	Phase 2/Phase 3
Recruiting	`NCT04283760` - Investigation of the Reliability and Validity of the Movement Imagination Questionnaire - Revised Second in Acute Stroke Patients
Recruiting	`NCT05454397` - A Study on the Status of Nutritional Risk Screening and Nutritional Therapy in Neurology Hospitalized Stroke Patients
Completed	`NCT04488692` - Early Functional Training in Acute Stroke Inpatient Ward	N/A
Recruiting	`NCT04214522` - Reliability and Validity of the Kinesthetic and Visual Imagery Questionnaire in Acute Stroke Patients
Not yet recruiting	`NCT04157231` - Essential Acute Stroke Care in Low Resource Settings: a Pilot studY	N/A
Recruiting	`NCT05469438` - IMAS Optimization and Applicability in an Acute Stroke Setting.