Acute Myocardial Infarction Clinical Trial
Official title:
Study on CircRNA-Uck2 as a New Diagnostic Marker of Acute Myocardial Infarction
This is an observational diagnostic study that aims to evaluate the diagnostic value of circRNA-Uck2 in Acute Myocardial Infarction (AMI) in adults as compared to healthy and unstable angina controls. Rapid and adequate diagnosis of AMI is of great importance to enable a rapid start of treatment, save large tracts of dying myocardium, reduce the infarct size,and thereby decrease the risk of subsequent heart failure.
RATIONAL acute myocardial infarction (AMI) is the leading cause of sudden death and heart
failure worldwide. And about 10% of all emergency department consultations are with symptoms
suggestive of AMI, however, only 10% to 20% of them are diagnosed as experiencing an AMI.
Rapid and accurate identification of AMI is of paramount clinical importance for subsequent
timely and effectively treatment and management.
Recently, the investigators identified microarray analysis and real-time polymerase chain
reaction (PCR) from AMI animal models and small samples of AMI patients, a molecular
signature of AMI involving 5 circRNAs (circRNA_006877, circRNA_015350, circRNA_002969,
circRNA_013240, circRNA_004682) was found significantly change in AMI patients and likely
serves as candidate serum biomarkers of AMI. Among the 5 circRNAs, circRNA_006877 name of
circRNA-Uck2 (cUck2) has more close association with AMI.
TYPE OF STUDY : multicenter diagnostic evaluation Study MAIN PURPOSE OF THE STUDY : To
evaluate the diagnostic value of circRNAs in AMI in adults as compared to healthy and
unstable angina controls
SECONDARY OBJECTIVES :
assess the ability of cUck2 to discriminate a AMI disease from unstable angina patients in
adults.
explore the relationship between cUck2 and heart function after myocardial infarction
PRODUCTS OF THE STUDY diagnostic kit of AMI in quantitative polymerase chain reaction (qPCR)
NUMBER OF PATIENTS : 3 groups with 169 patients will be included Group 1: 66 AMI adult
patients Group 2: 56 unstable angina adults Group 3: 56 Witnesses healthy adults INCLUSION
LENGTH 36 months DURATION OF THE STUDY 42 months
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT04451967 -
Acute Myocardial Infarction Study in Northeastern China
|
||
| Completed |
NCT05974397 -
Nationwide Trends in Incidence, Healthcare Utilization, and Mortality in Hospitalized Acute Myocardial Infarction Patients in Taiwan
|
||
| Not yet recruiting |
NCT04072081 -
Drug-coated Balloon Versus Drug-eluting Stent in the Treatment of Coronary Artery Lesions in STEMI Patients in De Novo Coronary Lesions
|
N/A | |
| Recruiting |
NCT03940443 -
Differences in Mortality and Morbidity in Patients Suffering a Time-critical Condition Between GEMS and HEMS
|
||
| Recruiting |
NCT03707626 -
Collateral Circulation to LAD and Wellens Sign
|
||
| Completed |
NCT02669810 -
EXCELLENT (EXpanded CELL ENdocardiac Transplantation)
|
Phase 2 | |
| Not yet recruiting |
NCT04104048 -
Short Term Outcome of Primary Precutaneous Coronary Intervention in Ostial Versus Non Ostial Culprit Proximal Left Anterior Descending Artery Acute Myocardial Infraction
|
||
| Active, not recruiting |
NCT02915107 -
The SORT OUT IX STEMI OCT Trial
|
N/A | |
| Completed |
NCT02896543 -
The Relationship of Change of Dendritic Cells Fractalkine and P-selectin Patients With Acute Myocardial Infarction
|
N/A | |
| Completed |
NCT02490969 -
Copeptin Registry (proCORE) Biomarkers in Cardiology (BIC)-19
|
N/A | |
| Completed |
NCT02531165 -
Platelet Inhibition After Pre-hospital Ticagrelor Using Fentanyl Compared to Morphine in Patients With ST-segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
|
N/A | |
| Withdrawn |
NCT01901471 -
Cyclosporine in Acute Myocardial Infarction Complicated by Cardiogenic Shock
|
Phase 2 | |
| Completed |
NCT02312336 -
A Pilot Study of Transcoronary Myocardial Cooling
|
N/A | |
| Recruiting |
NCT02071342 -
Study of ABSORB Stent in Acute Myocardial Infarction
|
N/A | |
| Completed |
NCT02070913 -
COOL-AMI EU Case Series Clinical Study
|
||
| Terminated |
NCT01972126 -
MAGNetic QRS-Fragmentation in Patients With Myocardial InfarcTion and Moderately RedUceD Ejection Fraction
|
N/A | |
| Completed |
NCT01216995 -
Safety and Efficacy of Adipose Derived Regenerative Cells (ADRCs) Delivered Via the Intracoronary Route in the Treatment of Patients With ST-elevation Acute Myocardial Infarction (AMI)
|
Phase 2 | |
| Withdrawn |
NCT01678339 -
Sicilian Administrative Data Base Study in Acute Coronary Syndrome Patients
|
N/A | |
| Completed |
NCT01887080 -
Effects of Microcurrent in a Cardiovascular Rehabilitation Home-based Program
|
N/A | |
| Completed |
NCT01673893 -
ClearWay Rx Readmission Registry
|