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Acute Ischemic Stroke clinical trials

View clinical trials related to Acute Ischemic Stroke.

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NCT ID: NCT06172387 Active, not recruiting - Clinical trials for Acute Ischemic Stroke

Intra-arterial Albumin in Acute Ischemic Stroke After Endovascular Treatment for

Start date: November 1, 2023
Phase: Phase 1
Study type: Interventional

Stroke is an acute focal injury of the central nervous system caused by cerebral vessels. One in every four people is affected by stroke at different times in life. Globally, stroke is the second leading cause of death and third leading cause of disability in adults. we hypothesized that in patients with acute large vessel occlusive ischemic stroke treated with mechanical thrombectomy, the infusion of 20% human serum albumin solution into the revascularization area can exert a stronger neuroprotective effect.

NCT ID: NCT06071091 Active, not recruiting - Clinical trials for Acute Ischemic Stroke

Permanent Intracranial Stenting for Acute Ischemic Stroke Related to a Refractory Large Vessel Occlusion

PISTAR
Start date: November 8, 2023
Phase: N/A
Study type: Interventional

Clot extraction failure during mechanical thrombectomy is a major concern in the management of acute ischemic stroke related to large vessel occlusions. Indeed, it can occur in up to 10 to 30% of cases and, therefore, is associated with a very poor prognosis. These refractory occlusions frequently occur when an underlying intracranial atherosclerotic disease is present. Thus, one of the most promising rescue technique consists of placing a permanent intracranial stent, under dual antiplatelet therapy over the target refractory occlusion. This strategy is well studied in coronary occlusions where the atheroscotic mechanism is highly prevalent. However, as the ischemiated brain is at much higher risk of hemorrhagic complications, such strategy entails a greater risk. This raises the question of whether such risk is worth the reward of obtaining reperfusion. The investigators designed this randomized study in order to evaluate whether a strategy combining rescue pemanent intracranial stenting with the best medical treatment is superior to the best medical treatment alone in acute refractory large vessel occlusions.

NCT ID: NCT06018545 Active, not recruiting - Clinical trials for Acute Ischemic Stroke

AI Assisted Reader Evaluation in Acute Computed Tomography (CT) Head Interpretation

AI-REACT
Start date: June 1, 2023
Phase:
Study type: Observational

This study has been added as a sub study to the Simulation Training for Emergency Department Imaging 2 study (ClinicalTrials.gov ID NCT05427838). The purpose of the study is to assess the impact of an Artificial Intelligence (AI) tool called qER 2.0 EU on the performance of readers, including general radiologists, emergency medicine clinicians, and radiographers, in interpreting non-contrast CT head scans. The study aims to evaluate the changes in accuracy, review time, and diagnostic confidence when using the AI tool. It also seeks to provide evidence on the diagnostic performance of the AI tool and its potential to improve efficiency and patient care in the context of the National Health Service (NHS). The study will use a dataset of 150 CT head scans, including both control cases and abnormal cases with specific abnormalities. The results of this study will inform larger follow-up studies in real-life Emergency Department (ED) settings.

NCT ID: NCT05700097 Active, not recruiting - Clinical trials for Acute Ischemic Stroke

Dengzhanxixin Injection for Acute Ischemic Stroke Receiving Reperfusion Therapy

Start date: September 30, 2022
Phase: Phase 2
Study type: Interventional

To assess the Efficacy and Safety of Dengzhanxixin Injection in Patients With Acute Ischemic Stroke Receiving Reperfusion Therapy.

NCT ID: NCT05281549 Active, not recruiting - Clinical trials for Acute Ischemic Stroke

Thrombolysis Treated With TNK-tPA in Acute Ischemic Stroke Patients (3T Stroke-II)

Start date: May 2, 2021
Phase: Phase 2
Study type: Interventional

The trial is prospective, block randomized, open-label, blinded endpoint (PROBE) design. Patients with acute ischemic stroke, who are eligible for standard intravenous thrombolysis within 4.5 hours of stroke onset will be randomized 1:1:1 to 0.25mg/kg or 0.40mg/kg intravenous tenecteplase or 0.9 mg/kg alteplase before all participants undergo endovascular thrombectomy.

NCT ID: NCT05188417 Active, not recruiting - Clinical trials for Acute Ischemic Stroke

A Study Evaluating the Safety and Efficacy of Tirofiban in Combination With Alteplase in Acute Ischemic Stroke

RESET
Start date: December 9, 2021
Phase: Phase 2
Study type: Interventional

The study is a prospective, multicenter, randomized, double-blind, placebo-controlled study evaluating the safety and efficacy of tirofiban in combination with intravenous thrombolytic therapy with alteplase in acute ischemic stroke

NCT ID: NCT05139147 Active, not recruiting - Clinical trials for Acute Ischemic Stroke

DAISe 1 Feasibility Study to Evaluate the DAISe Thrombectomy System for Acute Ischemic Stroke

Start date: January 12, 2022
Phase: N/A
Study type: Interventional

The study is a prospective, multi-center, single arm, feasibility study that will enroll a maximum of 36 subjects. The maximum enrollment is 10 subjects per site. A maximum of 6 investigational centers in Europe will participate. Enrollment is expected to take about 9 months, subject participation will last about 3 months.

NCT ID: NCT05070260 Active, not recruiting - Clinical trials for Acute Ischemic Stroke

ACTISAVE: ACuTe Ischemic Stroke Study Evaluating Glenzocimab Used as Add-on Therapy Versus placEbo

ACTISAVE
Start date: September 23, 2021
Phase: Phase 2/Phase 3
Study type: Interventional

A randomized, double blind, multicenter, multinational, placebo controlled, parallel group, single dose, adaptive phase II/III study. The study evaluates the efficacy and safety of a fixed dose of glenzocimab (1000 mg IV over 6 hrs including initial bolus of 15 minutes) on top of the best standard of care.

NCT ID: NCT05005962 Active, not recruiting - Clinical trials for Acute Ischemic Stroke

Prospective Registry for Assessment of Acute Ischemic Stroke Patients Treated With Neurothrombectomy Devices in India

PRAAN
Start date: August 30, 2021
Phase:
Study type: Observational [Patient Registry]

PRAAN is a post-market registry designed to collect real-world data associated with the use of Medtronic market release neurothrombectomy devices in acute ischemic stroke (AIS) patients from India.

NCT ID: NCT04951440 Active, not recruiting - Clinical trials for Acute Ischemic Stroke

Study on the Effectiveness and Safety of Nitrone for Injection in Patients With Acute Ischemic Stroke

Start date: June 1, 2018
Phase: N/A
Study type: Interventional

The main purpose of the study: To evaluate the effect of nitrosone 1 special for patients with acute ischemic cerebral stroke. The secondary purpose of the study: To evaluate the effectiveness of the injection of nitrosone I. T for loyal patients with acute ischemic stroke All women think.