Clinical Trials Logo
  1. Home
  2. Acute Coronary Syndrome
  3. NCT03486340
  4. Details
NCT03486340 Clinical Trial

Prevention of Chest Pain in Chemo-treated Cancer Patients

Acute Coronary Syndrome Clinical Trial

— CATCH  

Official title:
Prevention of CArdioToxic-related CHest Pain in Cancer Patients Treated With 5-fluorouracil

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT03486340
Other study ID # CATCH2018
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date April 11, 2018
Est. completion date June 30, 2025

Study information
Verified date September 2023
Source Vejle Hospital
Contact Mads D Lyhne, MD
Phone +45 20450486
Email Mads.Dam.Lyhne@rsyd.dk
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

This is a prospective, exploratory, randomised clinical trial. Patients with diagnosed cancer that are to be treated with 5-fluorouracil (5-FU) will be randomised into standard oncological treatment or a cardiological assessment prior to the 5-FU treatment. The investigators hypothesize that aggressive management of ischemic risk factors in asymptomatic patients will reduce the number of hospitalisations and investigations for acute coronary syndrome during and after 5-FU treatment and that patients with high coronary artery calcium scores are more likely to experience chest pain during the treatment with 5-FU.

Recruitment information / eligibility
Status Recruiting
Enrollment 200
Est. completion date June 30, 2025
Est. primary completion date December 30, 2024
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Histologically verified cancer - First-time treatment with 5-FU/Capecitabine - Expected remaining lifetime > 6 months - Informed consent Exclusion Criteria: - Known ischemic heart disease - Ischemia-suspicious symptoms prior to 5-FU treatment - Ischemia-suspicious ECG-changes prior to 5-FU treatment

Study Design

Related Conditions & MeSH terms

Intervention

Procedure:
• Cardiologic assessment
Aggressive ischemic risk factor management

Locations
Country Name City State
Denmark Departments of Oncology and Medicine, Vejle Hospital Vejle

Sponsors (2)
Lead Sponsor Collaborator
Vejle Hospital Region of Southern Denmark

Country where clinical trial is conducted

Denmark, 

Outcome
Type Measure Description Time frame Safety issue
Primary Acute coronary syndrome Composite endpoint of the incidence of overall mortality, chest pain requiring hospital admittance, the incidence of coronary angiography intervention and acute coronary syndrome 6 months
Secondary Chest pain Incidence of chest pain 6 months
See also
  Status Clinical Trial Phase
Recruiting NCT05846893 - Drug-Coated Balloon vs. Drug-Eluting Stent for Clinical Outcomes in Patients With Large Coronary Artery Disease N/A
Recruiting NCT06013813 - Conventional vs. Distal Radial Access Outcomes in STEMI Patients Treated by PCI N/A
Recruiting NCT05412927 - AngelMed Guardian® System PMA Post Approval Study
Completed NCT02750579 - Early or Delayed Revascularization for Intermediate and High-risk Non ST-elevation Acute Coronary Syndromes? N/A
Completed NCT04102410 - Assessing Force-velocity Profile: an Innovative Approach to Optimize Cardiac Rehabilitation in Coronary Patients N/A
Enrolling by invitation NCT03342131 - Serum Concentration of Wnt2 and Wnt4 in Patients With Acute Coronary Syndrome N/A
Recruiting NCT01218776 - International Survey of Acute Coronary Syndromes in Transitional Countries
Enrolling by invitation NCT04676100 - International CR Registry
Completed NCT03590535 - 5th Generation cTnT in ED ACS
Recruiting NCT05437900 - INSIGHTFUL-FFR Clinical Trial Phase 4
Completed NCT05551429 - Factors Related to Participation in Cardiac Rehabilitation in Patients With Acute Coronary Syndrome
Terminated NCT04316481 - IDE-ALERTS Continued Access Study N/A
Active, not recruiting NCT04475380 - Complex All-comers and Patients With Diabetes or Prediabetes, Treated With Xience Sierra Everolimus-eluting Stents
Not yet recruiting NCT04852146 - Electronic Feedback for Data Restitution and Valorization to the Emergency Teams in Aquitaine.
Active, not recruiting NCT02892903 - In the Management of Coronary Artery Disease, Does Routine Pressure Wire Assessment at the Time of Coronary Angiography Affect Management Strategy, Hospital Costs and Outcomes? N/A
Completed NCT04077229 - Piloting Text Messages to Promote Positive Affect and Physical Activity N/A
Not yet recruiting NCT02871622 - BMX Alpha Registry: a Post-market Registry of the BioMatrix Alpha TM N/A
Completed NCT02944123 - Half Dose of Prasugrel and Ticagrelor in Acute Coronary Syndrome (HOPE-TAILOR) Phase 3
Active, not recruiting NCT02922140 - The Impact of Pharmaceutical Care Practice on Patients in Cardiac Rehabilitation Unit N/A
Terminated NCT02620202 - Aiming Towards Evidence Based Interpretation of Cardiac Biomarkers in Patients Presenting With Chest Pain