| Eligibility |
1. Acute chest pain assessment in the Emergency department
Inclusion criteria
- Participant is willing and able to give informed consent for participation in the
study
- Male or Female, aged 18 years or above
Exclusion criteria
The participant may not enter the study if ANY of the following apply:
- Unable or unwilling to give valid consent for participation in the study
- Participant has been previously recruited to another module of the VECTRA ECG
study
- Participant has history of allergy to ECG electrode
- Noisy ECG trace in spite of appropriate preparation and elimination of mains
artefact and muscle tremor
- ECG tracing with a wandering baseline
- Sustained or non-sustained ventricular/atrial arrhythmia (Ventricular
tachycardia, supraventricular tachycardia, atrial fibrillation, bigeminy and
trigeminy)
- QRS duration greater than 120 milliseconds
- Q waves (except positional Q waves checked by deep inspiration)
- Suspected Septicaemia, pulmonary embolism or aortic dissection
- Recent history of trauma to thorax
- Severe renal impairment with eGFR <30 ml/min
2. Acute chest pain assessment in the Primary Care Surgery
Inclusion criteria
- Participant is willing and able to give informed consent for participation in the
study.
- Male or Female, aged 18 years or above.
- Participants who have experienced chest pain more than 6 hours but less than 2
weeks of presentation to the surgery
Exclusion criteria
The participant may not enter the study if ANY of the following apply:
- Unable or unwilling to give valid consent for participation in the study
- Participant has been previously recruited to another module of the VECTRA ECG
study
- Participant has history of allergy to ECG electrode
- Participants who have experienced 'Acute chest pain', defined as chest pain
occurring less than 6 hours prior to presentation at the surgery
- Participants whose initial Electrocardiogram reveals features compatible of ST
elevation Myocardial Infarction
- Participants whose initial Electrocardiogram reveals a Left Bundle branch block
suspected to be of new onset
- Noisy ECG trace in spite of appropriate preparation and elimination of mains
artefact and muscle tremor
- ECG tracing with a wandering baseline
- Sustained or non-sustained ventricular/atrial arrhythmia (Ventricular
tachycardia, Supraventricular tachycardia, atrial fibrillation, bigeminy and
trigeminy)
- QRS duration greater than 120 milliseconds
- Q waves (except positional Q waves checked by deep inspiration)
- Suspected Septicaemia, pulmonary embolism or aortic dissection
- Recent history of trauma to thorax
- Severe renal impairment with eGFR <30ml/min
3. Performance of CEB during inducible ischaemia in patients with stable angina
Inclusion criteria
- Participant is willing and able to give informed consent for participation in the
study.
- Male or Female, aged 18 years or above.
Exclusion criteria
The participant may not enter the study if ANY of the following apply:
- Unable or unwilling to give valid consent for participation in the study
- Participant has been previously recruited to another module of the VECTRA ECG
study
- Lack of adequate ultrasound acoustic window
- Contraindications to undergoing stress test using dobutamine
- Participant has history of allergy to ECG electrode
- Noisy ECG trace in spite of appropriate preparation and elimination of mains
artefact and muscle tremor
- ECG tracing with a wandering baseline
- Sustained or non-sustained ventricular/atrial arrhythmia (Ventricular
tachycardia, supraventricular tachycardia, atrial fibrillation, bigeminy and
trigeminy)
- QRS duration greater than 120milliseconds
- Q waves (except positional Q waves checked by deep inspiration)
- Suspected Septicaemia, pulmonary embolism or aortic dissection
- Recent history of trauma to thorax
- Severe renal impairment with eGFR <30 ml/min
4. Performance of CEB during acute ischaemia in patients undergoing percutaneous coronary
intervention (PCI)
Inclusion criteria
- Participant is willing and able to give informed consent for participation in the
study
- Male or Female, aged 18 years or above
- Participant diagnosed with stable CAD or stable ACS (unstable angina or NSTEMI
with no pulmonary oedema or cardiogenic shock at the time of recruitment)
- Participant with Single vessel coronary artery disease or multi- vessel disease
for target vessel PCI
Exclusion criteria
The participant may not enter the study if ANY of the following apply:
- Unable or unwilling to give valid consent for participation in the study
- Participant has been previously recruited to another module of the VECTRA ECG
study
- Participant has history of allergy to ECG electrode
- Participants known to have multi-vessel coronary artery disease with one or more
Chronic Total Occlusive lesions
- Severe Left main coronary artery stenosis
- Noisy ECG trace in spite of appropriate preparation and elimination of mains
artefact and muscle tremor
- ECG tracing with a wandering baseline
- Sustained or non-sustained ventricular/atrial arrhythmia (Ventricular
tachycardia, supraventricular tachycardia, atrial fibrillation, bigeminy and
trigeminy)
- QRS duration greater than 120 milliseconds
- Q waves (except positional Q waves checked by deep inspiration)
- Suspected Septicaemia, pulmonary embolism or aortic dissection
- Recent history of trauma to thorax
- Severe renal impairment with eGFR <30 ml/min
5. Performance of CEB in patients undergoing cardio-toxic treatment (type 1 and type 2
cytostatic based treatments of haemo-oncological patients
Inclusion criteria
- Participant is willing and able to give informed consent for participation in the
study.
- Male or Female, aged 18 years or above.
- Participants who have been given a diagnosis of cancer and are being commenced on a
chemotherapeutic drug deemed to be cardio-toxic
Exclusion criteria
The participant may not enter the study if ANY of the following apply:
- Unable or unwilling to give valid consent for participation in the study
- Participant has been previously recruited to another module of the VECTRA ECG study
- Participant has history of allergy to ECG electrode
- Participants previously diagnosed with Cardiomyopathy or Heart failure
- Lack of adequate ultrasound acoustic window
- Noisy ECG trace in spite of appropriate preparation and elimination of mains artefact
and muscle tremor
- ECG tracing with a wandering baseline
- Sustained or non-sustained ventricular/atrial arrhythmia (Ventricular tachycardia,
supraventricular tachycardia, atrial fibrillation, bigeminy and trigeminy)
- QRS duration greater than 120milliseconds
- Q waves (except positional Q waves checked by deep inspiration)
- Suspected Septicaemia, pulmonary embolism or aortic dissection
- Recent history of trauma to thorax
- Severe renal impairment with eGFR <30ml/min
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