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Achalasia Cardia clinical trials

View clinical trials related to Achalasia Cardia.

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NCT ID: NCT03784365 Recruiting - Achalasia Cardia Clinical Trials

Single-Versus Multiple-dose Antimicrobial Prophylaxis for Peroral Endoscopic Myotomy in Achalasia

SMAPP
Start date: October 1, 2018
Phase: Phase 3
Study type: Interventional

Achalasia cardia is a primary oesophageal motility disorder of unknown etiology characterized manometrically by oesophageal aperistalsis and insufficient relaxation of the lower oesophageal sphincter (LES) in response to deglutition. Causative mechanism is unknown but may be related to genetic predisposition or autoimmunity. Because of the unknown aetiology of achalasia, a curative treatment is not available. Palliative treatment options are aimed to reduce the gradient across the LES, alleviating the primary symptoms of dysphagia and regurgitation, improving esophageal emptying, and preventing the development of megaesophagus.

NCT ID: NCT03438838 Recruiting - Achalasia Cardia Clinical Trials

Randomised Trial Between LHM Alone Vs LHM With Anterior Fundoplication In Achalasia Cardia

Start date: January 24, 2018
Phase: N/A
Study type: Interventional

Back ground: Achalasia Cardia (AC) manifests with major symptom dysphagia. Surgery as the treatment modality relieves dysphagia in most of the patients. Laparoscopic Heller's myotomy(LHM) is the surgery of choice but is associated with gastroesophageal reflux. Anterior fundoplication (Dor Fundoplication) is usually combined with LHM in patients with AC. It reduces gastroesophageal reflux following LHM. It has been observed that along with reduction of gastroesophageal reflux Dor Fundoplication also affects relief of dysphagia. But it has not been prospectively studied. Hypothesis:The hypothesis of present study is that "Frequency of dysphagia following Laparoscopic Heller's myotomy with Dor fundoplication is more than that compared to Laparoscopic Heller's myotomy alone in patients with Achalasia Cardia". Methods: From December2017 to November 2018 minimum of 20 patients with diagnosis of Achalasia cardia will be randomized to receive either Laparoscopic Heller's myotomy (LHM) alone or LHM with Dor fundoplication. Symptomatic outcomes would be assessed using frequency of dysphagia and Eckardt's score. . Outcomes: Primary outcome is Frequency of dysphagia and secondary outcome is manometry pressure assessment. Statistical analysis would be done using Statistical Package for the Social Sciences (SPSS) soft ware. P value < 0.05 is considered significant.

NCT ID: NCT03186248 Not yet recruiting - Achalasia Cardia Clinical Trials

Randomized Clinical Trial Comparing Short Versus Long Oesophageal Myotomy in POEM for Achalasia Cardia.

Start date: July 15, 2017
Phase: N/A
Study type: Interventional

Aim of this study is to compare the outcomes of a short esophageal myotomy extending from 3 cm cephalad to the EGJ, to 3 cm distal to it with a long esophageal myotomy with an additional proximal extension (at least 6 cm cephalad to the EGJ, to 3 cm distal) for POEM procedures. Principle of POEM is to reduce pressure gradient across LES by Myotomy. Hypothesis is that performing short myotomy will result in similar efficacy in achalasia cardia while reducing the total time taken for the procedure and ultimately will result in less complications.

NCT ID: NCT02025790 Recruiting - Achalasia Cardia Clinical Trials

POEM Versus Pneumatic Dilatation in Achalasia Cardia

Start date: December 2013
Phase: N/A
Study type: Interventional

The aim of this study is to compare efficacy of POEM and pneumatic dilatation in treatment of achalasia cardia.